A multi-centre, randomized, open-label trial was conducted to evaluate the safety and efficacy of recombinant interferon (rIFN) alpha-2c versus rIFN gamma in patients with recurrent or persistent condylomata acuminata (CA). Thirty-three such patients were treated either with 6 μg rIFN alpha-2c or with 0.1 mg rIFN gamma (both equivalent to 2×10E6 IU), single dose, subcutaneously 3 times a week for 6 weeks. In case of no complete clearance at week 10, a second course of treatment with the other type of rIFN was given. There was no significant difference in the complete clearance proportions at week 10 between the two treatment groups (3/16 vs 6/17). No relapses occurred in these patients during the 16 weeks' follow-up. Further clearances during the follow-up resulted in a total complete clearance proportion of 14/33 at the end of study. The treatment was well tolerated. Repeated interferon therapy has its place in treating persistent or recurrent condylomas.
GissmannLWolnikLIkenbergHKoldouskyUSchnurchHGZurHausenH.Human papillomavirus types 6 and 11, DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci USA1983; 80: 560–3
2.
GissmannLDeVilliersEMZurHausenH.Analysis of human warts (condyloma acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int J Cancer1982; 29: 143–6
3.
Centers for Disease Control. Condyloma acuminatum, United States, 1966–1981. MMWR1983; 32: 306–8
4.
von KroghG.Podophyllotoxin for condylomata acuminata eradication: Clinical and experimental comparative studies on podophyllum lignans, colchicine and 5-fluouracil. Acta Dermatol Venereol1981; 98:(suppl.): 1–45
5.
WeckPhKBrandsmaJLWhisnantJK. Interferons in the treatment of human papillomavirus disease. Cancer Metast Rev1986; 5: 139–65
6.
SilvaPDMichaJPSilvaDG. Management of condyloma acuminatum. J Am Acad Dermatol1985; 13: 457–63
7.
von KroghGWikströmA.Efficacy of chemical and/or surgical therapy against condylomata acuminata: A retrospective evaluation. Int J STD AIDS1991; 2: 333–8
8.
KhawajaHT. Treatment of condyloma acuminatum. Lancet1986; 1: 208–9
9.
StoehrGPPetersonALTaylorWJ. Systemic complications of local podophyllin therapy. Ann Intern Med1978; 89: 362–3
10.
FerenczyAMitaoMNagaiNSilversteinSJ, Crum ChP. Latent papillomavirus and recurring genital warts. N Engl J Med1985; 313: 784–8
11.
PhKirby. Interferon and genital warts: Much potential, modest progress. JAMA1988; 259: 570–2
12.
ZennerHPKleyWClarosP. Recombinant interferon-alpha-2c in laryngeal papillomatosis: Preliminary results of a prospective multicentre trial. Oncology1985; 42 (suppl.1): 15–18
13.
MeriganTCReedSDHallTSTyrellDAJ. Inhibition of respiratory virus infection by locally applied interferon. Lancet1973; i: 563–7
14.
MeriganTCRandKHPollardRMAbdallahPSJordanGWFriedRP. Human leukocyte interferon for the treatment of herpes zoster in patients with cancer. N Engl J Med1978; 298: 981–7
15.
SundmacherRCantellKSkodaRHallermannChNeumann-HaefelinD.Human leukocyte and fibroblast interferon in a combination therapy of dendritic keratitis. Albrecht v Graefes Arch klin Exp Ophthal1978; 208: 229–33
16.
PazinGJArmstrongJALamMT. Prevention of reactivated herpes simplex infection by human leucocyte interferon after operation of trigeminal root. N Engl J Med1979; 301: 225–30
17.
ScullardGHLjudevitLAGreenbergHB. Antiviral treatment of chronic hepatitis B virus infection: Improvement in liver disease with interferon and adenine arabinoside. Hepatology1981; 1: 228–32
18.
ArvinAMKushnerJHFeldmanS.Human leukocyte interferon for the treatment of varicella in children with cancer. N Engl J Med1982; 306: 761–5
19.
TurekLPByrneJCLowyDRDvoretzkyIFriedmanRMHowleyPM. Interferon induces morphologic reversion with elimination of extrachromosomal viral genomes in bovine papillomavirus-transformed mouse cells. Proc Soc Exp Biol Med1982; 79: 7914–18
20.
Friedman-KienAEEronLJConantM. Natural interferon alfa for treatment of condylomata acuminata. JAMA1988; 259: 533–8
21.
GeffenJRKleinRJFriedman-KienAE. Intralesional administration of large doses of human leukocyte interferon for the treatment of condylomata acuminata. J Infect Dis1984; 150: 612–15
22.
GallStAHughesCTrofatterKF. Interferon for the therapy of condylomata acuminata. Am J Obstet Gynecol1985; 153: 157–63
23.
GallStAHughesCEMountsPhSegritiAWeckPhKWhisnantJK. Efficacy of human lymphoblastoid interferon in the therapy of resistant condylomata acuminata. Obstet Gynecol1986; 67: 643–51
24.
SchonfeldANitkeSSchattnerA. Intramuscular human interferon-β injections in treatment of condylomata acuminata. Lancet1984; i: 1038–42
25.
EronLJJudsonFTuckerSt. Interferon therapy for condylomata acuminata. N Engl J Med1986; 315: 1059–64
26.
KirbyPhKiviatNBeckmanAWellsDSherwinStCoreyL.Tolerance and efficacy of recombinant human interferon gamma in the treatment of refractory genital warts. Am J Med1988; 85: 183–8
27.
WelanderCEHomesleyHDSmilesKAPeetsEA. Intralesional interferon alfa-2b for the treatment of genital warts. Am J Obstet Gynecol1990; 162: 348–54
28.
WagnerDde VilliersE-MGissmannL.Der Nachweis verschiedener Papillomvirustypen in zytologischen Abstrichen von Praäkanzerosen und Karzinomen der Cervix uteri. Geburtsh u Frauenheilk1985; 45: 226–31
29.
MoellerBRJohannesenPOstherKUlmsteenUHastrupJBergK.Treatment of dysplasia of the cervical epithelium with an interferon gel. Obstet Gynecol1983; 62: 625–9
30.
ByrneMAMoellerBRTaylor-RobinsonD. The effect of interferon on human papillomaviruses associated with cervical intraepithelial neoplasia. Br J Obstet Gynaecol1986; 93: 1136–44
