In a prospective study to identify the viral type isolated from women undergoing screening for herpes simplex virus (HSV) during pregnancy using fluoroscine-labelled monoclonal antibodies to HSV-1 and HSV-2, HSV-2 was more likely to be isolated during the third trimester and was the only viral type isolated at term. As the severity of neonatal central nervous system disease is greater with HSV-2 than HSV-1 we recommend that all women with a history of genital herpes should be screened during pregnancy.
WhitleyRJNahmiasAJVisintineAMFlemingCLAlfordCA. The natural history of herpes simplex virus infection of mother and newborn. Paediatrics1980; 66: 489–94
2.
CoreyLWhitleyRJStoneEFMohanK.Difference between herpes simplex virus type 1 and 2 neonatal encephalitis neurological outcome. Lancet1988; i: 1–4
3.
BinkinNJKeplanJPCatesW.Preventing neonatal herpes: Value of weekly viral cultures in pregnant women with recurrent genital herpes. JAMA1984; 251: 2816–21
4.
WoolleyPDBowmanCAHicksDAKinghornGR. Virological screening for herpes simplex virus during pregnancy. BMJ1988; 296: 1642–3
5.
WittekAEYeagerASAuDSHensleighPA. Asymptomatic shedding of herpes simplex virus from the cervix and lesion site during pregnancy: Correlation of antepartum shedding with shedding at delivery. Am J Dis Child1984; 138: 439–42
6.
ArvinAMHensleighPAProberCG. Failure of antepartum maternal cultures to predict the infant's risk of exposure to herpes simplex virus at delivery. N Engl J Med1986; 315: 796–800
7.
ProberCGSullenderWMYasukawaLLAuDSYeagerASArvinAM. Low risk of herpes simplex virus infection in neonates exposed to the virus at the time of vaginal delivery to mothers exposed to recurrent genital herpes simplex virus infections. N Engl J Med1987; 316: 240–4
8.
KellyJ.Genital herpes during pregnancy: Routine virological screening is futile. BMJ1988; 296: 1140–7
9.
CarneyOMindelA.Screening pregnant women for genital herpes. BMJ1988; 296: 1643
10.
SullenderWMMillerJLYasukawaLL, Humoral and cell-mediated immunity in neonates with herpes simplex virus infections. J Infect Dis1987; 155: 28–37
11.
Sullivan-BolgaiJHullHFWilsonCCoreyL.Neonatal herpes simplex virus infection in Kings County, Washington. JAMA1983; 250: 3059–62
12.
WoolleyPDKudesiaG.Incidence of herpes simplex virus type 1 and type 2 from patients with primary genital herpes. Int J STD AIDS1990; 1: 184–7
