To investigate cell-mediated immune response in chancroid, soluble interleukin-2 receptor levels in serum and urine samples of healthy individuals and patients were measured by an enzyme-linked immunosorbent assay. Increased levels both in serum and in urine were observed in cases of Haemophilus ducreyi infection. In patients showing a prolonged incubation period, urine levels exceeded serum values. Therapy led to a reduction of elevated interleukin-2 receptor levels in serum and in urine.
GreenblattRMLukehartSAPlummerFAGenital ulceration as a risk factor for HIV infection. AIDS1988;2:47–50.
2.
SimonsenJNCameronDWGakinyaMNHIV infection among men with sexually transmitted diseases: Experience from a center in Africa. N Engl J Med1988;319:274–8.
3.
BallardRCDuncanMOFehlerHGDangorYExpostoFLLatifAS.Treating chancroid: Summary of studies in southern Africa. Genitourin Med1989;65:54–7.
4.
AbeckDJohnsonAPDangorYBallardRC.Antibiotic susceptibilities and plasmid profiles of Haemophilus ducreyi isolates from southern Africa. J Antimicrob Chemother1988;22:437–44.
5.
PizzoloGChilosiMVinanteFSoluble interleukin-2 receptors in the serum of patients with Hodgkin's disease. Br J Cancer1987;55:427–8.
6.
ScollardDMWagnerDKNelsonDL.Release of soluble interleukin-2 receptors (tac peptide) in vivo during immune response to tuberculin. Clin Immunol Immunpathol1988;46:450–5.
7.
MarconLFritzMEKurmanCCJensenJCNelsonDL.Soluble tac peptide is present in the urine of normal individuals and at elevated levels in patients with adult T cell leukaemia (ATL). Clin Exp Immunol1988;73:29–33.
8.
FleischmannJDWentworthDBThomasKMImbemboAL.Urinary interleukin-2 inhibition in patients with cystitis. Immunol Invest1989;18:825–31.
