Anti-pl7 was examined as a human immunodeficiency virus (HIV) marker predicting the onset of the acquired immunodeficiency syndrome (AIDS). Two different comparisons were done: (1)anti-pl7 negativity and successful HIV isolation; and (2)anti-pl7 negativity and clinical status, using the Centers for Disease Control classification. Anti-p17 negativity was not only significantly correlated with deterioration in clinical status (P<0.01), but also with successful HIV isolation (P<0.05). HIV isolation was affected by several drugs, e.g. zidovudine. However, the results of the antibody test were not affected. It is significant that anti-pl7 can compensate for the defects of virus isolation.
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