The British Association for Sexual Health and HIV United Kingdom guideline on the management of non-gonococcal urethritis (NGU) 2026 provides details on the aetiology and clinical features of NGU, with recommendations on diagnosis and treatment of acute and persistent/recurrent NGU. Non-gonococcal urethritis is characterised by urethral inflammation, and it can be infectious or non-infectious. The most common organisms causing NGU are Chlamydia trachomatis and Mycoplasma genitalium. Diagnosis of NGU is based on clinical history and evidence of an excess of polymorphonuclear leucocytes in the anterior urethra of symptomatic men. Nucleic acid amplification tests to determine the specific aetiology are used to guide treatment and reduce complications. Recommendations include advising patients to abstain from sexual intercourse until they and their partner(s) have completed treatment and follow-up to prevent re-infection.
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