Human Immunodeficiency Virus (HIV) infection remains a global public health concern due to its high morbidity and mortality rates, as well as the significant costs associated with treatment and healthcare services.
Objective
To determine the incidence of HIV and its associated factors among blood donors in the city of Medellín, Colombia.
Methods
A longitudinal study was conducted using secondary data from 23,122 repeat blood donors at a blood bank in Medellín. The cumulative incidence was estimated along with its 95% confidence interval. Pearson’s chi-square test, Fisher’s exact test, and relative risk calculations were used to identify associated factors.
Results
The HIV incidence was 9.1 per 10,000 donors (95% CI: 5.0–13.2). Subgroups with the highest incidence per 10,000 donors included those recruited through mobile blood drives (12.3), individuals under 40 years of age (12.0), men (11.3), and altruistic donors (10.6).
Conclusion
A relatively low number of new HIV cases was found among repeat donors. However, the identification of subgroups with higher incidence is critical for developing targeted strategies to ensure the safety of these priority populations and to enhance active epidemiological surveillance systems for HIV in the general population.
QiaoYCXuYJiangDX, et al.Epidemiological analyses of regional and age differences of HIV/AIDS prevalence in China, 2004–2016. Int J Infect Dis2019; 81: 215–220.
AndagoyaJZambranoDAlcivarC. PatiñoV. Perfil epidemiológico del VIH en Latinoamérica. Revista Científica Mundo de la Investigación y el Conocimiento2019; 3(1): 232–258.
Correa-RodasKCardona-AriasJAHiguita-GutiérrezLF. Prevalencia de VIH en personas trans atendidos en una institución prestadora de servicios de salud de Medellín-Colombia. Arch Med2021; 22(1): 37–45.
8.
LyTDMartinLDaghfalD, et al.Seven human immunodeficiency virus (HIV) antigen-antibody combination assays: evaluation of HIV seroconversion sensitivity and subtype detection. J Clin Microbiol2001; 39(9): 3122–3128.
9.
GarcíaFÁlvarezMBernalC, et al.Diagnóstico de laboratorio de la infección por el VIH, del tropismo viral y de las resistencias a los antirretrovirales. Enferm Infecc Microbiol Clín2011; 29(4): 297–307.
De la CruzRBarreraTVidalJ, et al.Marcadores serológicos de sífilis, hepatitis B y VIH en donantes de sangre en el Hospital Nacional Cayetano Heredia, Lima-Perú. Rev Méd Hered1999; 10(4): 137–143.
12.
MulugetaHDessieGWagnewF, et al.Seroprevalence and trend of human immunodeficiency virus among blood donors in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis2019; 19(1): 383.
13.
YuYXuJLiM. Prevalence of HIV infection among Chinese voluntary blood donors during 2010-2017: an updated systematic review and meta-analysis. Transfusion2019; 59(11): 3431–3441.
BecerraEHernánJ. Seroprevalencia de marcadores infecciosos: sífilis, HIV, hepatitis B, hepatitis c y caracterización de donantes del Hemocentro del centro oriente colombiano en el año 2013. Universidad Nacional de Colombia, 2014. Disponible en. https://repositorio.unal.edu.co/handle/unal/50414
16.
MedinaMForeroSSuescúnS. Prevalencia de marcadores serológicos en donantes de sangre en Boyacá, Colombia, 2014–2015. Rev Cubana Salud Publica2020; 46(1): e1415.
17.
CardonaJCortésMPatiñoJ. Seroprevalencia de marcadores de infecciones transmisibles por vía transfusional en banco de sangre en Colombia. Rev Saude Publica2012; 46(6): 950–959.
18.
VermeulenMChowdhuryDSwanevelderR, et al.HIV incidence in South African blood donors from 2012 to 2016: a comparison of estimation methods. Vox Sang2021; 116(1): 71–80.
19.
SingogoEChagomeranaMVan RynC, et al.Prevalence and incidence of transfusion-transmissible infections among blood donors in Malawi: a population-level study. Transfus Med2023; 33(6): 483–496.
20.
DoddRCrowderLHaynesJ, et al.Screening blood donors for HIV, HCV, and HBV at the American red Cross: 10-year trends in prevalence, incidence, and residual risk, 2007–2016. Transfus Med Rev2020; 34(2): 81–93.
21.
DomínguezA. Importancia clínica de la hemovigilancia. La gestión en la seguridad transfusional y la hemovigilancia. Asociación Mexicana de Medicina Transfusional, A.C2009; 2(1): S90–S94.
Abbott laboratories. HIV Ag/Ab Combo, 2014, pp. 1–8.
24.
SeriBMingaAGabdillardD, et al.Twenty-year evolution of hepatitis B virus and human immunodeficiency virus prevalence and incidence in voluntary blood donors in Côte d’Ivoire. Open Forum Infect Dis2018; 5(4): ofy060.
25.
SawanpanyalertPYanaiHKitsuwannakulS, et al.An estimate of the number of human immunodeficiency virus (HIV)-positive blood donations by HIV-seronegative donors in a northern Thailand HIV epicenter. Inf Disp1996; 174(4): 870–873.
26.
GlynnSKleinmanSSchreiberG, et al.Trends in incidence and prevalence of major transfusion-transmissible viral infections in US blood donors, 1991–1996. Retrovirus Epidemiology Donor Study (REDS). JAMA2000; 284(2): 229–235.
27.
JaryADientaSLeducqV, et al.Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali. BMC Infect Dis2019; 19(1): 1064.
28.
LuzEMarquesMNettoEM, et al.HIV, HTLV, and Hepatitis B and C infection in blood donors in Bahia, Brazil from 2008 to 2017. Viruses2022; 14(11): 2323.
Cardona-AriasJPalacios-MenaVDizu-CalambasK, et al.Seropositividad de VIH y factores asociados en donantes de un banco de sangre de la ciudad de Medellín-Colombia, 2005–2018. Acta Biol Colomb2020; 25(3): 383–393.
31.
Cardona-AriasJAHiguita-GutiérrezLF. Impact of COVID-19 pandemic on seroprevalence of HIV, HBV, HCV and HTLV I-II in a blood bank in Medellín, Colombia, 2019–2022. Trop Med Infect Dis2023; 8(2): 118.
32.
RamosRMHernández DíazEMiranda GómezO, et al.Incidencia de marcadores serológicos en donantes de sangre. Rev Cubana Med Mil2014; 43(4): 441–448.
