Abstract
Keywords
Introduction
Sexually transmitted infections (STIs) are a long-standing public health concern with increasing occurrence in several countries, including the US.1,2 The World Health Organization estimates that more than one million curable STIs are acquired every day globally. 3 According to the Centers for Disease Control and Prevention’s STI Surveillance Report, more than 2.5 million cases of syphilis, gonorrhea, and Chlamydia were reported in the US in 2022. 2 STIs are associated with detrimental effects to sexual and reproductive health and increased risk of HIV acquisition. STIs are also a frequent cause of social stigmatization. 3
Of the eight pathogens currently linked to the greatest incidence of STIs, four (hepatitis B, herpes simplex virus, HIV, and human papillomavirus) are viral infections for which clinical management can effectively prevent disease progression and reduce or eliminate transmissibility. The remaining four conditions - syphilis, gonorrhea, chlamydia, and trichomoniasis - can mostly be cured with inexpensive medications that have been available for clinical use for decades. 3 So, where and why are we failing?
While the increase in STI rates in the past years likely results from multiple factors, barriers for STI diagnosis and care have been widely acknowledged as key drivers. 4 Aiming to mitigate the rising rates of STIs in the second half of the 20th century, many countries have implemented free of charge, walk-in sexual health services. However, the availability of such facilities has dropped in the US since the 2000s, following cutbacks in public health funding.5,6 Moreover, with the establishment of the Affordable Care Act in 2014, the model of care for STIs has further shifted from sexual health clinics to primary care units. 7 Pros and cons of this shift have long been debated. 8 While this change may have favored STI care for the percentage of the population with access to primary care, 7 underserved populations including subgroups at higher risk of STIs may now be facing higher barriers to access STI management.9,10 More recently, during the COVID-19 pandemic, several countries reported cutbacks in STI prevention, treatment, and monitoring services that have not yet been fully reestablished.11–14
Barriers for timely diagnosis and treatment
A key principle of STI care is the timely management, including early diagnosis, treatment, and sexual partner(s) care. 4 Even for persons with access to private or government-funded health services, timely management of STIs may be limited. Walk-in services are often inaccessible, and scheduled appointments sometimes take place several weeks after the initial request. Some health insurance companies restrict the number of yearly appointments for its clients, resulting in suboptimal care for persons at high and recurrent risk of STIs who would benefit from further visits for testing and treatment. Additional limitations include copay and other expenses charged for services; complex and lengthy procedures for reimbursement of expenses; limited working hours in health facilities; institutional protocols that may delay provision of treatment until a diagnosis is confirmed; inability to extend investigation and treatment for uninsured sexual partners; and stigma in healthcare services, with providers often unfamiliar with sexual and gender diversity, or sometimes showing uneasiness when dealing with sexual practices perceived as unusual.15,16 Altogether, these and other barriers for STI management contribute to the persistence or even the expansion of transmission networks.
Scarcity of targeted STI prevention messages
Since the 1980s, STI prevention messages have been strongly linked to HIV prevention messages, as prophylactic strategies available in the first three decades of the HIV epidemic – condoms and reduction in the number of sexual partners – were effective to both. Prevention campaigns struggled to disseminate the notion that all sexually active persons were at risk for HIV and STIs to some degree, so condoms were recommended for all. In recent years, with the increasing focus on HIV biomedical prevention strategies for highly exposed individuals, prevention messages targeting other STIs have been relaxed. Since HIV biomedical prevention programs include periodic STI testing and early treatment if applicable, a synergistic mitigation of STIs is intrinsically accessible in this context.17,18 Meanwhile, opportunities to promote STI prevention for persons not receiving HIV biomedical prevention are scarce. 19
Approaches to mitigate STI trends adopted by AIDS Healthcare Foundation
Working closely with communities and relying on flexible operations, non-governmental organizations are well positioned to provide rapid, tailored, and innovative responses to issues that affect their target audience. AIDS Healthcare Foundation (AHF) has provided continued services for HIV prevention and care since 1987, currently supporting more than 2,024,299 clients in the U.S. and 44 other countries. In 2005, AHF implemented its first Wellness Center in Los Angeles, US, with free of charge, confidential services available for persons at need with no appointment required, initially focused on HIV diagnosis and on the management of bacterial STIs for male clients. Since then, AHF expanded the availability and scope of work of its Wellness Centers; currently, 35 facilities are open in 13 US States, assisting clients regardless of gender, race, ethnicity, sexual orientation, or income. The main characteristics of AHF Wellness Centers model of care include: Compilation of recent AHF advertisements.

Discussion
Recent epidemiological data has shown that the public health mission of controlling the spread and detrimental outcomes of STIs is far from being accomplished, despite the availability of inexpensive and curative treatments for the most prevalent STIs. Novel strategies should be developed to promote sexual health, improve STI prevention, and facilitate early diagnosis and care. Sexual health walk-in clinics may have a critical role in facilitating access to prevention, diagnostics, and treatment resources, particularly for underserved populations. Collaborations between government, health insurance companies, non-governmental organizations, communities, and other stakeholders are essential to develop an effective response to this challenging public health issue. Finally, healthcare providers working at all levels of care should receive training to deliver comprehensive sexual health services for all sexually active persons, regardless of gender, age, race, social condition, sexual orientation, or sexual practices.
Challenges that contribute with the persistence of STI transmission chains should be scrutinized, and potential solutions should be analyzed, tested whenever possible, and implemented according to local needs. AHF Wellness Centers have implemented bold strategies to remove barriers for STI prevention, diagnosis, and care in the US. This experience could be adapted and expanded to other settings, helping mitigate the spread and detrimental outcomes of STIs.
Footnotes
Author contributions
VIAS, MW and ASB conceived the study. VIAS, ASB, AG, WE, and LB developed the overall structure of the manuscript. AG provided monitoring data included in the manuscript. VIAS wrote the first draft, and all authors revised and approved the final version of the manuscript. VIAS and AG have directly accessed and verified the underlying data reported in the manuscript.
Declaration of conflicting interests
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Funding
The author(s) received no financial support for the research, authorship, and/or publication of this article.
