Monkeypox (MPXV) usually causes a mild and self-limited infection. To date there are no data about cidofovir for the treatment for MPXV in humans. We report a case of a 25 years-old Brazilian man with a concurrent diagnosis of acute HIV (human immunodeficiency virus) infection, primary syphilis and MPXV infection with a nasal lesion successfully treated with intravenous cidofovir.
LanierRTrostLTippinT, et al.Development of CMX001 for the treatment of poxvirus infections. Viruses2010; 2: 2740–2762.
4.
WeiHHuangDFortmanJ, et al.Coadministration of cidofovir and smallpox vaccine reduced vaccination side effects but interfered with vaccine-elicited immune responses and immunity to monkeypox. J Virol2009; 83: 1115–1125.
5.
SmeeDSidwellRSmeeD. F, et al.A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antivir ResAntiviral Research2003; 5757: 4141–5252.
6.
SmeeDF. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother2008; 19: DOI:10.1177/095632020801900302
7.
AndreiGSnoeckR. Cidofovir activity against poxvirus infections. Viruses2010; 2: 2803–2830.
8.
SiegristEASassineJ. Antivirals with activity against monkeypox: a clinically oriented review. Clinical Infectious Diseases2022; ciac622.
9.
BoeseckeCMoninMBvan BremenK, et al.Severe monkeypox-virus infection in undiagnosed advanced HIV infection. Infection2022. published online on August 15th 2022. DOI: 10.1007/s15010-022-01901-z
10.
HoffmannCJessenHWyenC, et al.Clinical Characteristics of monkeypox virus infections among men with and without HIV: a large outbreak cohort in Germany. HIV Medicinen.2022. published online on September 4th 2022. DOI: 10.1111/hiv.13378.
ThornhillJPBarkatiSWalmsleyS, et al.Monkeypox virus infection in humans across 16 countries — april–june 2022. N Engl J Med2022; 387: 679–691.
13.
PalichRBurrelSMonselG, et al.Viral loads in clinical samples of men with monkeypox virus infection: a French case series. Lancet Infect Dis2022; S1473309922005862.
