Unencapsulated penicillin-resistant Neisseria meningitidis ST-53 clonal complex strain causing symptomatic proctitis in an HIV-negative man who has sex with men: A case report
Restricted accessCase reportFirst published online September, 2022
Unencapsulated penicillin-resistant Neisseria meningitidis ST-53 clonal complex strain causing symptomatic proctitis in an HIV-negative man who has sex with men: A case report
We report a case of Neisseria meningitidis symptomatic proctitis in an HIV-negative man who has sex with men attending the genitourinary clinic in Malta. The proctitis was caused by a rare clinical unencapsulated penicillin-resistant N. meningitidis strain of the ST-53 clonal complex.
de VriesHJCNoriAVKiellberg LarsenH, et al.2021 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens. J Eur Acad Dermatol Venereol2021; 35: 1434–1443.
2.
LadhaniSNLucidarmeJParikhSR, et al.Meningococcal disease and sexual transmission: urogenital and anorectal infections and invasive disease due to Neisseria meningitidis. Lancet2020; 395: 1865–1877.
3.
UrwinRFeaversIMJonesDM, et al.Molecular variation of meningococcal serotype 4 antigen genes. Epidemiol Infect1998; 121: 95–101.
4.
JolleyKAMaidenMC. Automated extraction of typing information for bacterial pathogens from whole genome sequence data: Neisseria meningitidis as an exemplar. Euro Surveill2013; 18: 20379. DOI: 10.2807/ese.18.04.20379-en
5.
JolleyKABlissCMBennettJS, et al.Ribosomal multilocus sequence typing: universal characterization of bacteria from domain to strain. Microbiology2012; 158(Pt 4): 1005–1015.
6.
HillDMLucidarmeJGraySJ, et al.Genomic epidemiology of age-associated meningococcal lineages in national surveillance: an observational cohort study. Lancet Infect Dis2015; 15: 1420–1428.
7.
MacLennanJMRodriguesCMCBratcherHB, et al.Meningococcal carriage in periods of high and low invasive meningococcal disease incidence in the UK: comparison of UKMenCar1-4 cross-sectional survey results. Lancet Infect Dis2021; 21: 677–687.
8.
TzengYLBazanJATurnerAN, et al.Emergence of a new Neisseria meningitidis clonal complex 11 lineage 11.2 clade as an effective urogenital pathogen. Proc Natl Acad Sci USA2017; 114: 4237–4242.
