We report a case of HIV-1 superinfection in a patient with established HIV-2 infection. The patient was not taking antiretroviral therapy, in line with criteria in national guidelines, and reported no risk for infection with HIV-1. This case serves as a reminder that patients infected with HIV-2 remain susceptible to HIV-1 infection. The protective effect of antiretroviral treatment against HIV-1 infection should be a consideration in treatment decisions for individuals with HIV-2 infection.
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