We report a case of a concurrent reactivation of varicella zoster virus and herpes simplex virus in an immunocompromised patient unaware of her longstanding human immunodeficiency virus (HIV) infection. Despite being a rare event, concurrent reactivation of the two alphaherpesvirinae has been reported in various conditions, either in immunocompetent or immunocompromised patients. However, a reactivation in the same anatomical location in a person living with HIV seems to be an extremely rare event.
DhimanNWrightPAEspyMJ, et al.
Concurrent detection of herpes simplex and varicella-zoster viruses by polymerase chain reaction from the same anatomic location. Diagn Microbiol Infect Dis2011; 70(4): 538–40.
2.
Kahn G, Taubenhaus LJ. X-Ray Screening for Tuberculosis in Nursing-home Patients. J Am Geriatr Soc 1964; 12: 420–422.
3.
Gibney MD, Leonardi CL and Glaser DA. Concurrent herpes simplex and varicella-zoster infection in an immunocompromised patient. J Am Acad Dermatol 1995; 33: 126–129.
4.
Nikkels AF, Frère P, Rakic L et al. Simultaneous reactivation of herpes simplex virus and varicella-zoster virus in a patient with idiopathic thrombocytopenic purpura. Dermatology 1999; 199(4): 361–364.
5.
Krishnaram AS, Sachan Y, Rani GG. Co-reactivation of varicella zoster virus and herpes simplex virus with disseminated cutaneous lesions in a lymphoma patient. Indian J Dermatol Venereol Leprol 2013; 79(5): 709–711.
6.
Curley MJ, Hussein SA, Hassoun PM. Disseminated herpes simplex virus and varicella zoster virus coinfection in a patient taking thalidomide for relapsed multiple myeloma. J Clin Microbiol 2002; 40(6): 2302–2304
7.
Godet C, Beby-Defaux A, Landron C et al. Concomitant disseminated herpes simplex virus type 2 infection and varicella zoster virus primoinfection in a pregnant woman. Scand J Infect Dis 2005; 37(10): 774–776.
8.
Cupps TR, Straus SE, Waldmann TA. Successful treatment with acyclovir of an immunodeficient patient infected simultaneously with multiple herpesviruses. Am J Med 1981; 70(4): 882–886
9.
Lim ZV, Tey H. 2018. Disseminated herpes simplex virus and varicella zoster virus co-infection in an immunocompetent patient. Indian J Dermatol Venereol Leprol 2018; 84(2): 212–214.
10.
Park HH, Lee MH. Concurrent reactivation of varicella zoster virus and herpes simplex virus in an immunocompetent child. J Korean Med Sci 2004; 19(4): 598–600.
11.
Kobayashi T, Yagami A, Suzuki K, et al. Concurrent reactivation of herpes simplex and varicella zoster viruses confirmed by the loop-mediated isothermal amplification assay. Case Rep Dermatol 2014; 6: 5–9.
12.
Terasaki, S., T. Kameyama, and S. Yamamoto, A case of zoster in the 2nd and 3rd branches of the trigeminal nerve associated with simultaneous herpes labialis infection–a case report. Kurume Med J 1997; 44(1): 61–66.
13.
Theil D, Paripovic I, Derfuss T, et al. Dually infected (HSV-1/VZV) single neurons in human trigeminal ganglia. Ann Neurol 2003; 54: 678–682.
14.
Sloutskin A, Yee MB, Kinchington PR, et al. Varicellazoster virus and herpes simplex virus 1 can infect and replicate in the same neurons whether co- or superinfected. J Virol 2014; 88: 5079–5086.
15.
Meier JL and Straus SE. Comparative biology of latent varicella-zoster virus and herpes simplex virus infections. J Infect Dis 1992; 166: S13–S23.
16.
Miller AE. Selective decline in cellular immune response to varicella-zoster in the elderly. Neurology 1980; 30: 582–587.
17.
Berger R, Florent G and Just M. Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged. Infect Immun 1981; 32: 24–27.
18.
Landry ML and Hsiung GD. Diagnosis of dual herpes virus infection: varicella-zoster and herpes simplex virus. In: Nahmias AJ, Dowdle E and Schinazi RF (eds) The human herpesviruses. New York: Elsevier, 1978, pp.652–653.
19.
Hill TG. Herpes simplex virus latency. In: Roizman B (ed.) The herpesviruses. New York: Plenum, 1985, pp.174–240.
20.
Croen KD. Latency and the consequence of reactivation of the varicella-zoster virus. Ann Intern Med 1988; 108: 221–237.
21.
Straus SE. Clinical and biological differences between recurrent herpes simplex virus and varicella-zoster virus infections. JAMA 1989; 262: 3455–3458.
22.
Lungu O, Panagiotidis CA, Annunziato PW, et al. Aberrant intracellular localization of varicella-zoster virus regulatory proteins during latency. Proc Natl Acad Sci USA 1998; 95: 7080–7085.
23.
Lekas HM, Schrimshaw EW and Siegel K. Pathways to HIV testing among adults aged fifty and older with HIV/AIDS. AIDS Care 2005; 17: 674–687.
24.
Giehl KA, Müller-Sander E, Rottenkolber M, et al. Identification and characterization of 20 immunocompetent patients with simultaneous varicella zoster and herpes simplex virus infection. J Eur Acad Dermatol Venereol 2008; 22: 722–728.
25.
Piret J and Boivin G. Antiviral drug resistance in herpesviruses other than cytomegalovirus. Rev Med Virol 2014; 24: 186–218.
26.
Balfour HH Jr, Benson C, Braun J, et al. Management of acyclovir-resistant herpes simplex and varicella-zoster virus infections. J Acquir Immune Defic Syndr 1994; 7: 254–260.
27.
Dworkin RH, Johnson RW, Breuer J, et al. Recommendations for the management of herpes zoster. Clin Infect Dis 2007; 44: S1–26.
