Epidermolysis bullosa acquisita is a chronic subepidermal blistering disease associated with autoimmunity to type-VII collagen within anchoring fibrils located at the dermo-epidermal junction. This entity is rarely reported from India. It can have a variety of presentations. Its occurrence with retroviral disease has rarely been reported. Here, we present a case of epidermolysis bullosa acquisita in a patient with HIV infection.
WoodleyDTBurgesonRELunstrumGBruckner-TudermanLet al.Epidermolysis bullosa acquisita antigen is the globular carboxyl terminus of type VII procollagen. J Clin Invest1988; 81: 683–687.
BuijsroggeJJADiercksGFHPasHHet al.The many faces of epidermolysis bullosa acquisita after serration pattern analysis by direct immunofluorescence microscopy. Br J Dermatol2011; 165: 92–98.
7.
KimJHKimYHKimS-C. Epidermolysis bullosa acquisita: a retrospective clinical analysis of 30 cases. Acta Dermatol Venereol2011; 91: 307–312.
8.
ZumelzuCLe Roux-VilletCLoiseauPet al.Black patients of African descent and HLA-DRB115:03 frequency overrepresented in epidermolysis bullosa acquisita. J Invest Dermatol2011; 131: 2386–2393.
9.
GoddardGZShoenfeldY. HIV and autoimmunity. Autoimmun Rev2002; 1: 329–337.
10.
EtzioniA. Immune deficiency and autoimmunity. Autoimmun Rev2003; 2: 364–369.
11.
DematheAAredeLTMiyaharaGI. Mucous membrane pemphigoid in HIV patient: a case report. Cases J2008; 1: 345–345.
PricePMathiotNKruegerRet al.Immune dysfunction and immune restoration disease in HIV patients given highly active antiretroviral therapy. J Clin Virol2001; 22: 279–287.
14.
LehloenyaRMeintjesG. Dermatologic manifestations of the immune reconstitution inflammatory syndrome. Dermatol Clin2006; 24: 549–570.
15.
TsunodaKOtaTSuzukiHet al.Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris. Eur J Immunol2002; 32: 627–633.
16.
AmagaiMTsunodaKSuzukiHet al.Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest2000; 105: 625–631.
17.
UjiieHShibakiANishieWet al.Noncollagenous 16A domain of type XVII collagen-reactive CD4+ T cells play a pivotal role in the development of active disease in experimental bullous pemphigoid model. Clin Immunol2012; 142: 167–175.
18.
UjiieHShibakiANishieWet al.A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen. J Immunol2010; 184: 2166–2174.
19.
UjiieHShimizuH. Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models. Exp Dermatol2012; 21: 901–905.