We describe the case of a young girl with vertically-transmitted HIV infection who presented with chronic ocular inflammation characterized by several relapses and remissions. Good viral and immunological status made infective or neoplastic causes unlikely; the diagnosis was challenging and finally spontaneous remission was observed after several months. Clinical and histopathological findings made idiopathic orbital inflammatory syndrome the most probable diagnosis for our patient.
DegnanAJLevyLM. Orbital plasmablastic lymphoma with remission following chemotherapy. J Radiol Case Rep2011; 5: 1–7.
2.
AhFat-FGBatterburyM. Ophthalmic complications of HIV/AIDS. Postgrad Med J1996; 72: 725–730.
3.
HollandG. AIDS and ophthalmology: the first quarter century. Am J Ophthalmol2008; 145: 397–408.
4.
RhemNMWilhelmusKRJonesDB. Epstein-Barr virus dacryoadenitis. Am J Ophthalmol2000; 129: 372–375.
5.
MullerMWandelSColebundersR. Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis. Lancet Infect Dis2010; 10: 251–261.
6.
FrenchMA. Immune reconstitution inflammatory syndrome: immune restoration disease 20 years on. Med J Aust2012; 196: 318–321.
7.
LewisJHMahomed-YunusSMAnisaM. Incidence, clinical spectrum, risk factors and impact of HIV-associated immune reconstitution inflammatory syndrome in South Africa. PLoS One. Epub ahead of print 12 November 2012. DOI: 10.1371/journal.pone.0040623.
8.
HiroshiGMasahiroTAtsushiA. Japanese study group for IgG4-related ophthalmic disease. Diagnostic criteria for IgG4-related ophthalmic disease. Jpn J Ophthalmol2015; 59: 1–7.
9.
UmeharaHOkazakiKMasakiY. Comprehensive diagnostic criteria for IgG4-related disease (IgG4RD), 2011. Mod Rheumatol2012; 22: 21–30.
10.
Kubota T and Moritani S. Orbital IgG4-related disease: clinical features and diagnosis. ISRN Rheumatol. Epub ahead of print 21 June 2012. DOI: 10.5402/2012/412896.
11.
KaustubhMEktaAMehulJ. Orbital immunoglobulin-G4-related disease: case series and literature review. Clin Experiment Ophthalmol2014; 42: 682–687.
12.
KhosroshahiAStoneJH. A clinical overview of IgG4-related systemic disease. Curr Opin Rheumatol2011; 23: 57–66.
FrulloniLLunardiC. Serum IgG4 in autoimmune pancreatitis: a marker of disease severity and recurrence?Dig Liver Dis2011; 43: 674–675.
15.
HsuanJDSelvaDMcNabAA. Idiopathic sclerosing orbital inflammation. Arch Ophthalmol2006; 124: 1244–1250.
16.
YuenSJARubinPAD. Idiopathic orbital inflammation. Arch Ophthalmol2003; 121: 491–499.
17.
YumeiLGeraldL. Idiopathic orbital inflammation syndrome with retro-orbital involvement: a retrospective study of eight patients. PLoS One2013; 8: e57126–e57126.