Restricted accessCase reportFirst published online 2015-8
Drug interactions between voriconazole,darunavir/ritonavir and tenofovir/emtricitabine in an HIV-infected patient treated for Aspergillus candidus lung abscess
We report an unusual case of pulmonary aspergillosis in a patient with AIDS and we demonstrated the drug-drug interactions between voriconazole, darunavir/ritonavir and tenofovir/emtricitabine. The combination darunavir-ritonavir-voriconazole should be avoided.
EscamillaRHermantCPetureauF. [Disseminated aspergillosis with pulmonary and cardiac localization in an HIV-infected patient]. Revue des maladies respiratoires1995; 12: 380–382.
2.
HasseBStrebelBThurnheerR. Chronic necrotizing pulmonary aspergillosis after tuberculosis in an HIV-positive woman: an unusual immune reconstitution phenomenon?Aids2005; 19: 2179–2181.
3.
El FaneMOuladlahsenABakhatarA. [Pulmonary aspergillosis and HIV infection: about two cases]. Revue de pneumologie clinique2012; 68: 36–39.
4.
KellerMJSaxPE. Aspergillus sinusitis in two HIV-infected men. AIDS Clin Care1997; 9: 94, 100–94, 100.
5.
MartinezRCastroGMachadoAA. Primary aspergilloma and subacute invasive aspergillosis in two AIDS patients. Revista do Instituto de Medicina Tropical de Sao Paulo2009; 51: 49–52.
6.
Lee S, Kim BH, Nam WS, et al. Effect of CYP2C19 Polymorphism on the pharmacokinetics of voriconazole after single and multiple doses in healthy volunteers. J Clin Pharmacol 2011; 52: 195–203.
7.
MikusGSchowelVDrzewinskaM. Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir. Clin Pharmacol Ther2006; 80: 126–135.
8.
LiuPFosterGGandelmanK. Steady-state pharmacokinetic and safety profiles of voriconazole and ritonavir in healthy male subjects. Antimicrob Agents Chemother2007; 51: 3617–3626.
9.
ToyJGiguerePKravcikS. Drug interactions between voriconazole, darunavir/ritonavir and etravirine in an HIV-infected patient with Aspergillus pneumonia. Aids2011; 25: 541–542.
10.
AouriMDecosterdLABuclinT. Drug interactions between voriconazole, darunavir/ritonavir and etravirine in an HIV-infected patient with Aspergillus pneumonia. Aids2012; 26: 776–778.
