Human immunodeficiency virus-infected patients are at increased risk of drug reactions because of immune dysregulation and multiple drug intake. Lichenoid drug reactions to isoniazid have been reported previously in the literature. However, for lichenoid drug reaction to isoniazid to be so extensive to present as exfoliative dermatitis is rare. We report here a rare case of lichenoid drug reaction to isoniazid presenting as exfoliative dermatitis in a patient with acquired immunodeficiency syndrome.
PattersonJWBerryADDarwinBS. Lichenoid histopathological changes in patients with clinical diagnoses of exfoliative dermatitis. Am J Dermatopathol1991; 13: 358–364.
2.
BattegayMOpravilMWuthrickB. Rash with amoxicillin clavulanate therapy in HlV-infected patients. Lancet1989; 2: 1100–1100.
3.
BayardPJBergerTGJacobsonMA. Drug hypersensitivity reactions and HIV disease. J Acquir Immune Defic Syndr1992; 5: 1237–1257.
4.
ToddG. Adverse cutaneous drug eruptions and HIV: a clinician’s global perspective. Dermat Clin2006; 24: 459–472.
5.
NaranjoCABustoUSellersEM. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther1981; 30: 239–245.
6.
GrunwaldMDavidMFeuermanEJ. Appearance of lupus erythematosus in a patient with lichen planus treated by isoniazid. Dermatologica1982; 165: 172–177.
ViswanathBKRankaPRamanjanayaluM. Severe cutaneous adverse reactions due to isoniazid in a HIV Positive patient. Indian J Lepr2012; 84: 227–232.
11.
LehloenyaRJWallaceJToddG. Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients. Int J Tuberc Lung Dis2012; 16: 1260–1264.
12.
RosinMAKingLEJr. Isoniazid-induced exfoliative dermatitis. South Med J1982; 75: 81–81.
13.
KarakayliGBeckhamGOrengoT. Exfoliative dermatitis. Am Fam Physician1999; 59: 625–630.
14.
AlmeydaJLevantineA. Drug reactions XVI. Lichenoid drug eruptions. Br J Dermatol1971; 85: 604–607.
15.
HalevySShaiA. Lichenoid drug eruptions. J Am Acad Dermatol1993; 29: 249–255.
16.
BreathnachSMLichen planus and lichenoid disorders. In: BurnsTBreathnachSCoxNGriffithsC (eds). Rook’s textbook of dermatology, 8th ed. Oxford: Wiley-Blackwell, 2010, pp. 41.24–41.24.
17.
LehloenyaRJToddGMogotlaneL. Lichenoid drug reaction to antituberculosis drugs treated through with topical steroids and phototherapy. J Antimicrob Chemother2012; 67: 2535–2537.
18.
Van Den HauteVAntoineJLLachapelleJM. Histopathological discriminant criteria between lichenoid drug eruption and idiopathic lichen planus: retrospective study on selected samples. Dermatologica1989; 179: 10–13.
19.
OsawaJNaitSAiharaM. Evaluation of skin test reactions in patients with non-immediate type drug eruptions. J Dermatol1990; 17: 235–239.
20.
LammintaustaKKorteKangas-SavolainenO. Oral challenge in suspected cutaneous adverse drug reactions. Acta Derm Venerol2005; 85: 491–496.
21.
AlankoKKaupinnenKDiagnosis of drug eruptions: clinical evaluation and drug challenge. In: KaupinnenKAlankoKHannukselaMMaibachH (eds). Skin reactions to drugs, Boca Raton: CRC, 1998, pp. 75–79.
