A case of a 31-year-old man with systemic Penicillium marneffei infection acquired in Thailand and who developed endophthalmitis is described. This presentation has not previously been reported. He responded to combined treatment with intravenous and intravitreal amphotericin.
HilmarsdottirIMeynardJLRogeauxO. Disseminated Penicillium marneffei infection associated with human immunodeficiency virus: A report of two cases and a review of 35 published cases. J Acquir Immune Defic Syndr1993;6:466–71
2.
PetoTEABullRMillardPR. Systemic mycosis due to Penicillium marneffei in a patient with antibody to human immunodeficiency virus. J Infect1988;16:285–90
3.
SupparatpinyoKChiewchanvitSHirunsriPUthammachaiCNelsonKESirisanthanaT. Penicillium marneffei infection in patients infected with human immunodeficiency virus. Clin Infect Dis1992;14:871–4
4.
SupparatpinyoKKhamwanCBaosoungVNelsonKESirisanthanaT. Disseminated Penicillium marneffei infection in Southeast Asia. Lancet1994;344:110–13
5.
DuongTA. Infection due to Penicillium marneffei, an emerging pathogen: Review of 155 reported cases. Clin Infect Dis1996;23:125–30
ImwidthayaP. Update of Penicilliosis marneffei in Thailand. Mycopathologia1994;127:1357
8.
ConnorDH, eds. Pathology of Infectious Diseases, Vol II. Stanford: Appleton and Lange, 1997:1055–8
9.
BorradoriLSchmitJCStetzkowskiMDussoixPSauratJHFilthuthI. Penicilliosis marneffei infection in AIDS. J Am Acad Dermatol1994;31:843–6
10.
SirisanthanaTSupparatpinyoKPerriensJNelsonKE. Amphotericin B and itraconazole for the treatment of disseminated Pencillium marneffei infection in human immunodeficiency virus-infected patients. Clin Infect Dis1998;26:1107–10
11.
SupparatpinyoKNelsonKEMerzWG. Response to antifungal therapy by human immunodeficiency virus-infected patients with disseminated Penicillium marneffei infections and in vitro susceptibilities of isolates from clinical specimens. Antimicrob Agents Chemother1993;37:2407–11
12.
SupparatpinyoKPerriensJNelsonKESirisanthanaT. A controlled trial of itraconazole to prevent relapse of Penicillium marneffei infection in patients infected with the human immunodeficiency virus. N Engl J Med1998;339:1739–43
13.
MinogueMJPlayfairJFGregoryJCRobinsonLP. Cure of Paecilomyces endophthalmitis with multiple intravitreal injections of amphotericin B. Arch Ophthalmol1989;107:1281
14.
KokIVeenstraJRietraPJGMDirks-GoSBlaauwgeersJLGWeigelHM. Disseminated Penicillium marneffei infection as an imported disease in HIV-1 infected patients. Netherlands J Med1994;44:18–22
