Intranasal 7-thia-8-oxoguanosine (NARI 10146) compared with placebo had no influence on the course of experimental coronavirus 229E infections in human volunteers. Possible reasons are discussed for the failure to confirm successful rodent experiments in man.
References
1.
AokiF.Y.ReedS.E.CraigJ.W.TyrrellD.A.J., and LeesL.J. (1978) Effect of a polynucleotide interferon of fungal origin on experimental rhinovirus infection in humans. J Infect Dis137: 82–86.
2.
BeareA.S., and ReedS.E. (1977) The study of antiviral compounds in volunteers. In: Chemoprophylaxis and Virus Infections of the Respiratory Tract (ed. OxfordJ.), Vol 2, pp. 27–55. CRC Press, Inc., Cleveland.
3.
CallowK. (1985) Effect of specific humoral immunity and some non-specific factors on resistance of volunteers to respiratory coronavirus infection. J Hyg (Camb)95: 173–189.
4.
DorschH.M.OsundwaV., and LamP. (1988) Activation of human B lymphoctyes by 8′ substituted guanosine derivatives. Immunol Lett17: 125–132.
5.
GoodmanM.G., and HennenW.J. (1986) Distinct effects of dual substitution on inductive and differentiative activities of C8-substituted guanine ribonucleosides. Cell Immunol102: 395–402.
6.
HigginsP.G.BarrowG.I.GalbraithA.W.FrostH., and TyrrellD.A.J. (1989) A note on the failure of CGP 19835 A (MTP-PE) to influence the course of influenza A2 infection in human volunteers. Antiviral Res12: 49–52.
7.
JinA.MhaskarS.JolleyW.B.RobinsR.K., and Ojo-AmaizeE.A. (1990) A novel guanosine analog, 7-Thia-8-Oxoguanosine, enhances macrophage and lymphocyte antibody-dependent cell-mediated cytotoxicity. Cell Immunol126: 414–419.
8.
KooG.C.JewellM.E.ManyakC.L.SigalN.H., and WickerD.S. (1988) Activation of murine natural killer cells and macrophages by 8-bromoguanosine. J Immunol140: 3249–3252.
9.
NagaharaK.AndersonJ.D.KiniG.D.DalleyN.K.LarsonS.B.SmeeD.F.JinA.SharmaB.S.JolleyW.B.RobinsR.K., and CottamH.B. (1990) The sythesis of certain 3-β-D-ribofuranosylthiazolo[4,5-d] pyrimidines as potential immunotherapeutic agents. J Med Chem33: 407–415.
10.
Ojo-AmaizeE.RubalcavaB.AveryT.CottamH.B.MatsumotoS.S.JolleyW.B.RobinsR.K. (1991) Activation of the respiratory burst in murine phagocytes by certain guanine ribonucleosides modified at the 7 and 8 positions: possible involvement of a pertussis toxin-sensitive G protein. Immunol Lett23: 173–178.
11.
SmeeD.F.AlaghamandanH.A.CottamH.B.SharmaB.S.JolleyW.B., and RobinsR.K. (1989) Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent. Antimicrob Agents Chemother33, 1487–1492.
12.
SmeeD.F.AlaghamândanH.A.BatlettM.I., and RobinsR.K. (1990a) Intranasal treatment of picornavirus and coronavirus respiratory infections in rodents using 7-thia-8-oxoguanosine. Antiviral Chem Chemother1: 47–52.
13.
SmeeD.F.AlaghamandanH.A.CottamH.B.JolleyW.B., and RobinsR.K. (1990b) Antiviral activity of the novel immune modulator 7-thia-8-oxoguanosine. J Biol Response Mod9: 24–32.
14.
WickerL.S.BoltzR.C.NicholsE.A.MillerB.J.SigalN.H., and PetersonL.B. (1987) Large activated B cells are the primary B-cell target of 8-bromoguanosine and 8-mercaptoguanosine. Cell Immunol106, 318–329.
