The human hand is a versatile organ that performs a variety of activities in daily life. The coordination of digits allows them to deal with objects of various sizes and shapes with an appropriate range of motions (ROM). A systematic literature review was performed to identify the clinical and non-clinical factors which affected the normal ROM, grip strength (GS), and dexterity of hand. The overall outcomes of the systematic review showed that: the performance of the individual declined as the age progressed; the performance of the dominant hand (DH) of an individual was better compared to his/her non-dominant hand (NDH); the tasks performed by a healthy hand was more efficient compared to a diseased one; appropriate rehabilitation programs/exercise techniques after a disease or injury improved the ROM, GS, and dexterity of hand post-surgery on par to a healthy hand.
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