Nowadays, biopsy is a decisive method of lung cancer diagnosis, whereas lung biopsy is time-consuming, complex and inaccurate. So a computed tomography–compatible robot for rapid and precise lung biopsy is developed in this article. According to the actual operation process, the robot is divided into two modules: 4-degree-of-freedom position module for location of puncture point is appropriate for patient’s almost all positions and 3-degree-of-freedom tendon-based orientation module with remote center of motion is compact and computed tomography–compatible to orientate and insert needle automatically inside computed tomography bore. The workspace of the robot surrounds patient’s thorax, and the needle tip forms a cone under patient’s skin. A new error model of the robot based on screw theory is proposed in view of structure error and actuation error, which are regarded as screw motions. Simulation is carried out to verify the precision of the error model contrasted with compensation via inverse kinematics. The results of insertion experiment on specific phantom prove the feasibility of the robot with mean error of 1.373 mm in laboratory environment, which is accurate enough to replace manual operation.
SiegelRLMillerKDJemalA. Cancer statistics, 2015. CA Cancer J Clin2015; 65(1): 5–29.
2.
HenschkeCIYankelevitzDFLibbyDM. Survival of patients with stage I lung cancer detected on CT screening. N Engl J Med2006; 355(17): 1763–1771.
3.
WalshCJHanumaraNCSlocumAH. A patient-mounted, telerobotic tool for CT-guided percutaneous interventions. J Med Dev2008; 2(1): 011007-1–011007-10.
4.
OhnoYHatabuHTakenakaD. CT-guided transthoracic needle aspiration biopsy of small (≤20 mm) solitary pulmonary nodules. AJR Am J Roentgenol2003; 180(6): 1665–1669.
5.
MaurinBBayleBPiccinO. A patient-mounted robotic platform for CT-scan guided procedures. IEEE T Bio-Med Eng2008; 55(10): 2417–2425.
6.
HungrNFouardCRobertA. Interventional radiology robot for CT and MRI guided percutaneous interventions. In: Proceedings of the medical image computing and computer-assisted intervention (MICCAI 2011), Toronto, ON, Canada, 18–22 September 2011, pp.137–144. Berlin, Heidelberg: Springer.
7.
HadavandMNaishMDPatelRV. A parallel remote center of motion mechanism for needle-based medical interventions. In: Proceedings of the international conference on biomedical robotics and biomechatronics (RAS & EMBS 2014), Sao Paulo, Brazil, 12–15 August 2014, pp.1–6. New York: IEEE.
8.
ClearyKZigmundBBanovacF. Robotically assisted lung biopsy under CT fluoroscopy: lung cancer screening and phantom study. Int Congr Ser2005; 1281: 740–745.
9.
BadaanSPetrisorDKimC. Does needle rotation improve lesion targeting?Int J Med Robot2011; 7(2): 138–147.
10.
ZhouYThiruvalluvanKKrzeminskiL. CT-guided robotic needle biopsy of lung nodules with respiratory motion—experimental system and preliminary test. Int J Med Robot2013; 9(3): 317–330.
11.
LiMKapoorAMaziluD. Pneumatic actuated robotic assistant system for aortic valve replacement under MRI guidance. IEEE T Bio-Med Eng2011; 58(2): 443–451.
12.
MelzerAGutmannBRemmeleT. INNOMOTION for percutaneous image-guided interventions. IEEE Eng Med Biol Mag2008; 27(3): 66–73.
13.
FrancoEBrujicDReaM. Needle-guiding robot for laser ablation of liver tumors under MRI guidance. IEEE/ASME T Mech2015; 2(21): 931–944.
14.
LarsonBTErdmanAGTsekosNV. Design of an MRI-compatible robotic stereotactic device for minimally invasive interventions in the breast. J Biomech Eng2004; 126(4): 458–465.
15.
JiangSLouJYangZ. Design, analysis and control of a novel tendon-driven magnetic resonance-guided robotic system for minimally invasive breast surgery. Proc IMechE, Part H: J Engineering in Medicine2015; 229(9): 652–669.
16.
KuoCHDaiJSDasguptaP. Kinematic design considerations for minimally invasive surgical robots: an overview. Int J Med Robot2012; 8(2): 127–145.
17.
HeXRoppeneckerDGierlachD. Toward clinically applicable steady-hand eye robot for vitreoretinal surgery. In: Proceedings of the ASME 2012 international mechanical engineering congress and exposition, Houston, TX, 9–15 November 2012, pp.145–153. New York: ASME.
18.
KuoCHDaiJS. Kinematics of a fully-decoupled remote center-of-motion parallel manipulator for minimally invasive surgery. J Med Dev2012; 6(2): 021008-1–021008-12.
19.
JiangSSunFDaiJ. Design and analysis of a tendon-based MRI-compatible surgery robot for transperineal prostate needle placement. Proc IMechE, Part C: J Mechanical Engineering Science. Epub ahead of print 7May2014. DOI: 10.1177/0954406214533783.
20.
BassanHSPatelRVMoallemM. A novel manipulator for percutaneous needle insertion: design and experimentation. IEEE/ASME T Mech2009; 14(6): 746–761.
21.
JiangSLouJSunF. Modeling and control of a high-precision tendon-based magnetic resonance imaging–compatible surgical robot. Proc IMechE, Part I: J Systems and Control Engineering. Epub ahead of print 6May2015. DOI: 10.1177/0959651815581739.
22.
ChenYYangZJiangS. Registration technique of robot-aided image guided surgery. J Comput-Aided Des Comput Gr2015; 27(5): 953–960 (in Chinese).
23.
BottemaORothB. Theoretical kinematics. North Chelmsford, MA: Courier Corporation, 1990.
24.
MurrayRMLiZSastrySS. A mathematical introduction to robotic manipulation. Boca Raton, FL: CRC Press, 1994.
LiPJiangSSuZ. Experimental study of needle–tissue interaction forces: effect of needle geometries, insertion methods and tissue characteristics. J Biomech2014; 47(13): 3344–3353.
27.
YuYPodderTZhangY. Robot-assisted prostate brachytherapy. In: Proceedings of medical image computing and computer-assisted intervention (MICCAI 2006), Copenhagen, 1–6 October 2006, pp.41–49. Berlin, Heidelberg: Springer.
28.
NajafiMAbolmaesumiPRohlingR. Single-camera closed-form real-time needle tracking for ultrasound-guided needle insertion. Ultrasound Med Biol2015; 41(10): 2663–2676.
29.
EslamiSShangWLiG. In-bore prostate transperineal interventions with an MRI-guided parallel manipulator: system development and preliminary evaluation. Int J Med Robot2015; 12(2): 199–213.
30.
SuHShangWColeG. Piezoelectrically actuated robotic system for MRI-guided prostate percutaneous therapy. IEEE/ASME T Mech2015; 20(4): 1920–1932.
