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Abstract

In this paper, gas dynamics and temperature distribution of a transient impinging jet, typically used to deliver powdered drug or vaccines ballistically to the skin, have been numerically simulated. Calculations were performed with the unsteady compressible Navier-Stokes equations, solved using a modified implicit flux vector splitting (MIFVS) difference scheme with a modified k-e model. After validation against an experimental underexpanded jet-flow test cast, the code was applied to two biolistic configurations. Firstly, calculated pressure histories were compared with corresponding measurements in an unsilenced biolistic device, with good agreement. Secondly, this calculation was extended to a silenced geometry, with an emphasis on the gas properties immediately above a skin target. A peak stagnation gas temperature of 420°C is revealed within 175 μs of diaphragm rupture. The temperature of the following driver helium gas suddenly drops to below - 100°C before approaching ambient temperature within 1 ms. The effect of this impinging jet on the human skin is subsequently explored by a one-dimensional convection heat transfer model. On the skin surface, a peak fluctuation of [+5.5°C, - 4.5°C] is.recorded during the operation process. Beyond the outer skin layer, called the stratum corneum (i.e. > 10.6μ), temperature deviations from the normal condition are trivial. Therefore, the heat transfer between the biolistic jet and skin is negligible. This result is consistent with pain-free clinical trial observations.

Keywords

numerical simulation impingement unsteady heat transfer supersonic jet gene gun biolistics

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References

Bellhouse

B. J.

Sarphie

D. F.

Greenford

J. C.

Needle-less syringe using supersonic gas flow for particle delivery. Int. Pat. WO94/24263, 1994.

Bellhouse

B. J.

Quinlan

N. J.

Ainsworth

R. W.

Needle-less delivery of drugs, in dry powder form, using shock waves and supersonic gas flow. In Proceedings of the 21st International Symposium on Shock Waves, Queensland, Australia, 1997.

Kendall

M. A. F.

The delivery of particulate vaccines and drugs to human skin with a practical, hand-held shock tube-based system. Shock Waves J., 2002, 12 (1), 22–30.

Quinlan

N. J.

Gas and particle dynamics in transdermal powdered drug delivery. DPhil thesis, University of Oxford, Oxford, 1999.

Liu

Kendall

M. A. F.

Truong

N. K.

Bellhouse

B. J.

Numerical and experimental analysis of a high speed needle-free powdered vaccines delivery device. In Proceedings of the 20th AIAA Applied Aerodynamics Conference, St Louis, Missouri, 2002, paper AIAA-2002–2807.

Burkoth

T. L.

Bellhouse

B. J.

Hewson

Longridge

D. J.

Muddle

A. G.

Sarphie

D. F.

Transdermal and transmucosal powdered drug delivery. Critical Rev. Therapeutic Drug Carrier Systems, 1999, 16, 331–384.

Chen

Maa

Haynes

J. R.

Needle-free epidermal powder. Expert. Rev. Vaccines, 2002, 1 (3), 89–100.

Loehr

B. I.

Wilson

Babiuk

L. A.

van Drunen Little-van den Hurk

Gene gun-mediated DNA immunization primes development of mucosal immunity against bovine herpes virus 1 in cattle. J. Virol., 2000, 74, 6077–6086.

Wrighton-Smith

P. J.

Delivery of particles by powder injection. DPhil thesis, Unvirsity of Oxford, Oxford, 2003.

10.

Kendall

M. A. F.

Mitchell

T. J.

Wrighton-Smith

Intradermal ballistic delivery of micro-particles into excised human skin for pharmaceutical applications. J. Biomecha-nics, 2004 (in press).

11.

Mitchell

T. J.

Kendall

M. A. F.

Bellhouse

B. J.

A ballistic study of micro-particle penetration to the oral mucosa. Int. J. Impact Engng, 2003, 28 (6), 581–599.

12.

Kendall

M. A. F.

Rishworth

Carter

Mitchell

T. J.

Effects of relative humidity and ambient temperature on the ballistic delivery of micro-particles to excised porcine skin. J. Investigative Dermatol., 2004, 122, 739–746.

13.

Mulholland

W. M.

Kendall

M. A. F.

Bellhouse

B. J.

White

Analysis of microparticle penetration into human and porcine skin: Non-invasive imaging with multiphoton excitation microscopy. In SPIE Microscopy International Conference, San Jose, California, 2002.

14.

Kendall

M. A. F.

Mulholland

W. M.

Tirlapur

U. K.

Arbuthnott

E. S.

Armitage

Targeted delivery of micro-particles to epithelial cells for immunotherapy and vaccines: An experimental and probabilistic study. In the 6th International Conference on Cellular Engineering, Sydney, Australia, 2003.

15.

Kendall

M. A. F.

Mitchell

T. J.

Hardy

M. P.

De-Focatiis

The deformation of mucosal tissue subjected to an impinging gas jet: Experiments and numerical modelling. Biomater. J., March 2004 (submitted).

16.

Jambunathan

Lai

Moss

Button

A review of heat transfer data for single circular jet impingement. Int. J. Heat and Fluid Flow, 1992, 13, 106–115.

17.

Viskanta

Heat transfer to impinging isothermal gas and flame jets. Expl Thermal Fluid Sci., 1993, 6, 111–134.

18.

Webb

C.-F.

Single-phase liquid jet impingement heat transfer. Adv. Heat Transfer, 1995, 26, 105–217.

19.

Rahimi

Owen

Mistry

Impingement heat transfer in an under-expanded axisymmetric air jet. Int. J. Heat and Mass Transfer, 2003, 46, 263–272.

20.

Liu

Kendall

M. A. F.

Bellhouse

B. J.

An efficient implicit finite-difference scheme for transonic flow. In the 32nd AIAA Fluid Dynamics Conference and Exhibit, St Louis, Missouri, 2002, paper AIAA 2002–2955.

21.

Liu

Kendall

M. A. F.

Costigan

Bellhouse

B. J.

Prediction of jet flows from the axisymmetric supersonic nozzle. In Proceedings of the 24nd International Symposium on Shock Waves, Beijing, People's Republic of China, 2004.

22.

Wilcox

D. C.

Turbulence Modelling for CFD, 2nd edition, 1998 (DCW Industries Inc., La Canada, California).

23.

Behnia

Parneix

Shabany

Durbin

P. A.

Numerical study of turbulent heat transfer in confined and unconfined impinging jet. Int. J. Heat and Fluid Flow, 1999, 20, 1–9.

24.

Merci

Dick

Heat transfer predictions with a cubic Î°-Ïμ model for axisymmetric turbulent jets impinging onto a flat plate. Int. J. Heat and Mass Transfer, 2003, 46, 469–480.

25.

Igra

Takayama

Shock tube study of the drag coefficient of a sphere in a non-stationary flow. Proc R. Soc. Lond. A, 1993, 442, 231–247.

26.

Liu

Kendall

M. A. F.

Bellhouse

B. J.

Numerical investigations of a high speed powdered particle delivery system. In Fifth International Conference on Simulations in Biomedicine, Ljubljana, Slovenia, 2003.

27.

Hardy

M. P.

Numerical investigation of gas-powered delivery of micro-particles to tissue. DPhil thesis, University of Oxford, Oxford, 2003.

28.

29.

Swain

W. E.

Heydenburg Fuller

M. S.

Barr

L. J.

Fuller

J. T.

Culp

Burkholder

Dixon

R. M.

Widera

Vessey

Roy

M. J.

Tolerability and immune responses in humans to a PowderJect DNA vaccine for hepatitis B. Dev. Biology, 2000, 104, 115–119.

Numerical simulation of heat transfer from a transonic jet impinging on skin for needle-free powdered drug and vaccine delivery

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