Sage Journals: Discover world-class research

Abstract

Two thermoplastic poly(ether-urethane-urea)s were synthesized from isophorone diisocyanate, hexamethylene diamine, and polyethylene glycol as macrodiol. The molecular weight of the macrodiol was 2000 g mol⁻¹. The polymers have been characterized by means of transmission electron microscopy, ¹H-NMR, infrared spectroscopy, and other techniques. The hydrolytic stability of these materials was investigated under in vitro condition using Ringer's solution and phosphate-buffered saline. The stability of these series was compared with a poly(ether-urethane) prepared from isophorone diisocyanate, polyethylene glycol and 1,4-butanediol. The in vitro study revealed possible use of poly(ether-urethane-urea)s for long-term biomedical applications.

Get full access to this article

View all access options for this article.

References

[1] Ferguson J and Patsavoudis D 1987 Eur. Polym. J. 8 385

[2] Chang YJP and Wilkers GL 1975 J. Polym. Sci. Polym. Phys. Ed. 13 455

[3] Van Bogart JWC, Bluemke DA and Cooper SL 1981 Polymer 22 1428

[4] Koberstein JT and Gancarz I 1986 J. Polym. Sci. Polym. Phys. B24 2487

[5] Kazmierczak ME, Fornes RE, Buchanan DR and Gilbert RD 1989 J. Polym. Sci, Polym Phys B27 2173

[6] Kazmierczak ME, Fornes RE, Buchanan DR and Gilbert RD 1989 J. Polym. Sci, Polym. Phys. B27 2189

[7] Hun SL and Shaw LH 1989 Macromolecules 22 1100

[8] Petrovic ZS and Ferguson J 1991 Prog. Polym. Sci. 16 695

[9] Sreenivasan K 1991 Eur. Polym. J. 27 811

10.

[10] Koberstein JT and Leung LM 1992 Macromolecules 25 6205

11.

[11] Chu B, Gao T, Li Y, Wang J, Desper CR and Byrne CA 1992 Macromolecules 25 5724

12.

[12] Kim BK and Lee YM 1992 Colloid. Polym. Sci. 270 956

13.

[13] Li Y, Gao T and Chu B 1992 Macromolecules 25 1737

14.

[14] Wilkers GL, Bagrodia S, Humphries W and Wildnauer R 1975 Polymer Lett. 13 321

15.

[15] Lelah MD and Cooper SL 1986 Polyurethane in Medicine ( Boca Raton FL: CRC Press ) p. 23

16.

[16] Plank H, Syre I, Danner M and Egbers G (eds) 1987 Polyurethane in Biomedical Engineering: Progress in Biomedical Engineering ( Amsterdam: Elsevier ) pp. 197-212

17.

[17] Kolff WJ and Yu LS 1989 Ann. Thorac. Surg. 48 598

18.

[18] Stokes K and Cobian K 1982 Biomaterials 3 225

19.

[19] Stokes K 1988 J. Biomater. Appl. 3: 228

20.

[20] Stokes K, Coursy A and Urbanski P 1989 J. Biomater. Appl. 1 411

21.

[21] Stokes K, Urbanski P and Upton J 1990 J. Biomater. Sci. Polymed. 1 207

22.

[22] Coury AJ, Slaiken PC, Clahalas PT, Stokes K and Hobot CM 1988 J. Biomater. Appl. 3 130

23.

[23] Takahara A, Takamori K and Kajiyama T 1988 in Artificial Heart 2 TA Kutsu (ed) ( Tokyo: Springer Verlag ) p. 1095

24.

[24] Schollenberger CS and Stewart FD 1971 J. Elast. Plast. 3 28

25.

[25] Strizinar I and Sefton M 1992 J. Biomed. Mater. Res 26 577

26.

[26] Marconi W, Martinelli A, Piozzi A and Zone Z 1994 Macromol. Chim. Phyz. 195 875

27.

[27] Marconi W, Gallopa A, Martinelli A and Piozzi A 1995 Biomaterials 16 449

28.

[28] Mark HF, Gaylorad NG and Bikales NM 1996 Encyclopedia of Polymer Science & Technology vol 4 ( London: Interscience ) p 331

29.

[29] Bernacca GM, Mackay TGWilkinson R and Wheatley DJ 1995 Biomaterials 16 279

30.

[30] Bernacca GM, Mackay TG and Wheatley DJ 1996 J. Heart Valve Dis. 5 538

Hydrolytic Stability of Some Thermoplastic Poly(Ether-Urethane-Urea)s

Abstract

Get full access to this article

References