Abstract
Background
The association between alopecia areata (AA) and atopic dermatitis (AD) is common. The association of both autoimmune diseases is an indicator of poor prognosis. We hereby discuss the off-label therapeutic role of tofacitinib as concurrent treatment for both the conditions and long-term safety data.
Case report
Herein we describe a 5-year-old girl with alopecia areata and atopic dermatitis refractory to combination therapy of methotrexate and atopic dermatitis, who was started on tofacitinib 5 mg once daily. Due to inadequate response, the dose was escalated to 5 mg twice daily. The child achieved complete hair regrowth except for the ophiasis pattern and complete clearance of AD. The child was maintained on tofacitinib for the long term due to the risk of flare of both conditions.
Conclusion
We emphasize the long-term safety of tofacitinib in dermatological conditions like AA and AD. There are minimal case reports of long-term efficacy and use of tofacitinib in concurrent conditions.
Get full access to this article
View all access options for this article.
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
