This study examined and compared wound healing between Thai propolis product and calcium hydroxide paste as pulp-capping agents after partial pulpotomy in New Zealand white rabbits. Forty incisor teeth from 10 rabbits were treated. Thirty-six teeth received class V cavity preparations with partial pulpotomy and application of either propolis or calcium hydroxide paste. Similar cavity preparations were performed in 2 teeth without any capping material as a positive control, whereas 2 teeth without the cavity preparation served as a negative control. Histological evaluation showed that both groups had dentin bridge formation. Dentinal tubules in the dentin bridge were more orderly arranged in the Thai propolis group than in the calcium hydroxide group. Wound healing and the median number of hyperemic blood vessels were not statistically significant different between the 2 groups. Thai propolis product may be used as a pulp-capping agent.
HiltonTJ. Keys to clinical success with pulp capping: a review of the literature. Oper Dent. 2009;34(5):615–625.
2.
WardJ. Vital pulp therapy in cariously exposed permanent teeth and its limitations. Aus Endod J. 2002;28(1):29–37.
3.
ForemanPCBarnesIE. Review of calcium hydroxide. Int Endod J. 1990;23(6):283–297.
4.
MassEZilbermanU. Long-term radiologic pulp evaluation after partial pulpotomy in young permanent molars. Quintessence Int. 2011;42(7):547–554.
5.
AguilarPLinsuwanontP. Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod. 2011;37(5):581–587.
6.
ChailertvanitkulPPaphangkorakitJSooksantisakoonchaiN. Randomized control trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars. Int Endod J. 2014;47(9):835–842.
7.
CoxCFSübayRKOstroESuzukiSSuzukiSH. Tunnel defects in dentine bridges: their formation following direct pulp capping. Oper Dent. 1996;21(1):4–11.
8.
ParirokhMTorabinejadM. Mineral trioxide aggregate: a comprehensive literature review—part I: chemical, physical, and antibacterial properties. J Endod. 2010;36(1):16–27.
9.
TorabinejadMParirokhM. Mineral trioxide aggregate: a comprehensive literature review—part II: leakage and biocompatibility investigations. J Endod. 2010;36(2):190–202.
10.
ParirokhMTorabinejadM. Mineral trioxide aggregate: a comprehensive literature review—part III: clinical applications, drawbacks, and mechanism of action. J Endod. 2010;36(3):400–413.
11.
SabirATabbuCRAgustionoPSosrosenoW. Histologic analysis of rat dental pulp tissue capped with propolis. J Oral Sci. 2005;47(3):135–138.
12.
ParoliaAKundabalaMRaoNN. A comparative histological analysis of human pulp following direct pulp capping with Propolis, mineral trioxide aggregate and Dycal. Aus Dent J. 2010;55(1):59–64.
13.
AhangariZNaseriMJaliliMMansouriYMashhadiabbasFTorkamanA. Effect of propolis on dentine regeneration and the potential role of dental pulp stem cell in Guinea pigs. Cell J. 2012;13(4):223–228.
14.
OzórioJECarvalhoLFde OliveiraDAde Sousa-NetoMDPerezDE. Standardized propolis extract and calcium hydroxide as pulpotomy agents in primary pig teeth. J Dent Child. 2012;79(2):53–58.
15.
MarcucciMC. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie. 1995;26(2):83–99.
16.
BanskotaAHTezukaYKadotaS. Recent progress in pharmacological research of propolis. Phytother Res. 2001;15(7):561–571.
17.
PrueksakornAPuasiriSRuangsriS. The preservative effect of Thai propolis extract on the viability of human periodontal ligament cells. Dent Traumatol. 2016;32(6):495–501.
18.
ChailertvanitkulPNamsirikulTDamrongrungruangTPeerapattanaJ. Phenolic and flavonoids contents and antibacterial activity of ethanolic extract of propolis. lsan J Pharm Sci. 2017;13(3):59–67.
19.
Institute of Laboratory Animal Research, Division on Earth and Life Science, eighth edition, National Research Council of the National Academies. National Academy of Science. Washington, DC: The National Academies Press; 2011.
20.
AeinehchiMEslamiBGhanbarihaMSaffarAS. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. Int Endod J. 2003;36(3):225–231.
21.
AsgarySEghbalMJParirokhMGhanavatiFRahimiH. A comparative study of histologic response to different pulp capping materials and a novel endodontic cement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(4):609–614.
22.
RungcharassaengNKlanritPChailertvanitkulP. Wound healing between Thai propolis product and calcium hydroxide in direct pulp capping using a whole tooth culture model. Khon Kaen Dent J. Accepted for Publication.
23.
ParoliaAThomasMSKundabalaMMohanM. Propolis and its potential uses in oral health. Int J Med Sci. 2010;2(7):210–215.
24.
StübingerSDardM. The rabbit as experimental model for research in implant dentistry and related tissue regeneration. J Invest Surg. 2013;26(5):266–282.
25.
MaparaMThomasBSBhatKM. Rabbit as an animal model for experimental research. Dent Res J. 2012;9(1):111–118.
26.
AljandanBAlHassanHSaghahARasheedMAliAA. The effectiveness of using different pulp-capping agents on the healing response of the pulp. Indian J Dent Res. 2012;23(5):633–637.
27.
DavidovićLĆukMSandićMŽGrgaDŽivkovićS. The influence of liners on the pulp inflammation. Srp Arh Celok Lek. 2015;143(5-6):261–266.
28.
PrasadPDonoghueM. A comparative study of various decalcification techniques. Indian J Dent Res. 2013;24(3):302–308.
29.
GuptaSJawandaMKSmMBhartiA. Qualitative histological evaluation of hard and soft tissue components of human permanent teeth using various decalcifying agents—a comparative study. J Clin Diag Res. 2014;8(9):ZC69–ZC72.
