An anti-plaque gel, containing no pharmaceutical chemicals, alcohol, xylitol, artificial or synthetic ingredients, with clinically proven plaque reducing efficacy was evaluated as a toothpaste together with toothbrushing. The study was designed to achieve an optimal level of homecare and an effective degree of plaque reduction following professional periodontal therapy to aid in the management of periodontal disease. The study consisted of two blinded trials (medium/large dogs and small breed dogs) of 4-weeks duration, each of which included 45 dogs divided equally among a test group, a positive control group, and a negative control group. Significant reductions in both plaque (p < 0.001) and gingivitis (p < 0.001) were observed in the test group in comparison to both the negative and positive control groups. This study also demonstrated that plaque was significantly reduced in the gingival segment (p < 0.001) in addition to the whole tooth score (p < 0.001). No adverse effects were noted and brushing was well tolerated by all dogs. This study establishes a highly effective method for achieving plaque reduction in dogs.
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