Introduction: This study examined the relationship between person-centered perioperative nursing care and spiritual support perception of nurses working in surgical units. Design: In this descriptive and correlational study, 426 surgical nurses working in Türkiye between March and November 2024 constituted the sample. Data were collected using Google Forms through a personal information form, the Person-Centered Perioperative Nursing Scale, and the Perception of Spiritual Support Scales. Participants were reached using a virtual snowball sampling method. Results: The mean of the person-centered perioperative nursing scale was 80.07 ± 9.22, and spiritual support scale was 51.13 ± 6.78. There was a statistically significant difference between the institution of employment, participation in a conference on surgical nursing, and any training on person-centered perioperative care and the person-centered perioperative nursing scale (p < 0.05). Person-centered perioperative nursing had a statistically significant and positive effect on the perception of spiritual support (β = 0.265, p < 0.05), and 13% of the variance in the model was explained. Conclusion: The study found that person-centered perioperative care effectively promoted the perception of spiritual support. Therefore, nurses working in surgical settings are recommended to receive training on person-centered perioperative care to improve their perception of spiritual support, thereby enabling them to provide holistic care.