Purpose: The study's purposes were: (a) to explore the impact of mindfulness interventions regarding ease and confidence in the Certified Registered Nurse Anesthesia (CRNA) and Masters’ Entry Advanced Generalist Nursing (MEAGN) graduate nursing programs and (b) to assess and compare the perceptions of mindfulness interventions between students in the CRNA and MEAGN programs. Study design: Descriptive study utilizing pre- and posttest survey instruments. Method: A total of 77 student registered nurse anesthetists (SRNAs) (n = 46) and MEAGN students (n = 31) participated in a mindfulness intervention prior to course activities. The four mindfulness interventions used were music, meditation, guided breathing, and positive affirmation. Data were analyzed using descriptive statistics from pre- and postintervention surveys. Findings: The mindfulness intervention was positively received by students in both programs, as reflected in the confidential pre- and postsurveys. The majority of students in both programs (SRNA and MEAGN) reported feeling more at ease and felt the mindfulness intervention was worthwhile, a sentiment not widely expressed in the presurveys. This mindfulness intervention had a notable impact on students’ mental status and perceptions.