Purpose: This pilot study was conducted to determine the effectiveness of mindfulness practices, including self-compassion and yoga, on depression and/or anxiety in uninsured and/or low-income patients. Design: The design was repeated measures with one group. Method: Patients received 8 weeks of mindfulness training including self-compassion and yoga. Depression and anxiety symptoms, self-compassion, and psychological well-being were measured four times. Findings: Interventions were effective in helping uninsured and low-income patients reduce depression and/or anxiety symptoms. Conclusion: This study may have implications for a cost-effective treatment for these disorders. The findings from this study can provide useful information to health care providers.