Circular RNAs (circRNAs) are a unique class of noncoding RNAs that are formed post-transcriptionally, unlike all other classes of ncRNAs that are transcribed from the genome. They are the only class of RNAs that are closed loops with no 5′ and 3′ ends. Recent studies showed that mammals form >100,000 unique circRNAs that contain only exons, only introns, or both exons and introns. circRNAs are formed and degraded by various mechanisms, which are specific to this class of RNAs. This review article discusses the functional significance of circRNAs in the pathophysiology of traumatic brain injury and spinal cord injury, with an emphasis on their functionality in controlling mechanisms such as inflammation, oxidative stress, apoptosis, autophagy, neuronal plasticity, neuroprotection, and functional recovery, which are all important for outcomes after an acute central nervous system injury.
ChandranR, MehtaSL, VemugantiR. Non-coding RNAs and neuroprotection after acute CNS injuries. Neurochem Int, 2017; 111:12–22; doi: 10.1016/j.neuint.2017.01.015
5.
PatelA, DharapA. An Emerging Role for Enhancer RNAs in Brain Disorders. Neuromolecular Med, 2024; 26(1):7; doi: 10.1007/s12017-024-08776-3
6.
SongP, HanR, YangF. Super enhancer lncRNAs: A novel hallmark in cancer. Cell Commun Signal, 2024; 22(1):207; doi: 10.1186/s12964-024-01599-6
7.
MehtaSL, DempseyRJ, VemugantiR. Role of circular RNAs in brain development and CNS diseases. Prog Neurobiol, 2020; 186:101746; doi: 10.1016/j.pneurobio.2020.101746
8.
LiML, WangW, JinZB. Circular RNAs in the Central Nervous System. Front Mol Biosci, 2021; 8:629593; doi: 10.3389/fmolb.2021.629593
9.
ZengX, LinW, GuoM, et al.A comprehensive overview and evaluation of circular RNA detection tools. PLoS Comput Biol, 2017; 13(6):e1005420; doi: 10.1371/journal.pcbi.1005420
10.
JeckWR, SorrentinoJA, WangK, et al.Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013; 19(2):141–157; doi: 10.1261/rna.035667.112
MemczakS, JensM, ElefsiniotiA, et al.Circular RNAs are a large class of animal RNAs with regulatory potency. Nature, 2013; 495(7441):333–338; doi: 10.1038/nature11928
AktaşT, Avşar Ilıkİ, MaticzkaD, et al.DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature, 2017; 544(7648):115–119; doi: 10.1038/nature21715
15.
Ashwal-FlussR, MeyerM, PamudurtiNR, et al.circRNA biogenesis competes with pre-mRNA splicing. Mol Cell, 2014; 56(1):55–66; doi: 10.1016/j.molcel.2014.08.019
16.
ConnSJ, PillmanKA, ToubiaJ, et al.The RNA binding protein quaking regulates formation of circRNAs. Cell, 2015; 160(6):1125–1134; doi: 10.1016/j.cell.2015.02.014
17.
IvanovA, MemczakS, WylerE, et al.Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Rep, 2015; 10(2):170–177; doi: 10.1016/j.celrep.2014.12.019
18.
BarrettSP, WangPL, SalzmanJ. Circular RNA biogenesis can proceed through an exon-containing lariat precursor. Elife, 2015; 4:e07540; doi: 10.7554/eLife.07540
19.
HeJ, XieQ, XuH, et al.Circular RNAs and cancer. Cancer Lett, 2017; 396:138–144; doi: 10.1016/j.canlet.2017.03.027
20.
KopczynskiCC, MuskavitchMA. Introns excised from the Delta primary transcript are localized near sites of Delta transcription. J Cell Biol, 1992; 119(3):503–512; doi: 10.1083/jcb.119.3.503
21.
QianL, VuMN, CarterM, et al.A spliced intron accumulates as a lariat in the nucleus of T cells. Nucleic Acids Res, 1992; 20(20):5345–5350; doi: 10.1093/nar/20.20.5345
22.
ZhangY, ZhangXO, ChenT, et al.Circular intronic long noncoding RNAs. Mol Cell, 2013; 51(6):792–806; doi: 10.1016/j.molcel.2013.08.017
23.
RenL, JiangQ, MoL, et al.Mechanisms of circular RNA degradation. Commun Biol, 2022; 5(1):1355; doi: 10.1038/s42003-022-04262-3
24.
LiX, ZhangJ-L, LeiY-N, et al.Linking circular intronic RNA degradation and function in transcription by RNase H1. Sci China Life Sci, 2021; 64(11):1795–1809; doi: 10.1007/s11427-021-1993-6
25.
ParkOH, HaH, LeeY, et al.Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP complex. Mol Cell, 2019; 74(3):494–507.e498; doi: 10.1016/j.molcel.2019.02.034
26.
FischerJW, BusaVF, ShaoY, et al.Structure-Mediated RNA Decay by UPF1 and G3BP1. Mol Cell, 2020; 78(1):70–84.e76; doi: 10.1016/j.molcel.2020.01.021
27.
PanZ, LiG-F, SunM-L, et al.MicroRNA-1224 splicing circularRNA-Filip1l in an Ago2-Dependent manner regulates chronic inflammatory pain via targeting Ubr5. J Neurosci, 2019; 39(11):2125–2143; doi: 10.1523/jneurosci.1631-18.2018
28.
PiweckaM, GlažarP, Hernandez-MirandaLR, et al.Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science, 2017; 357(6357):eaam8526; doi: 10.1126/science.aam8526
29.
GuoY, ZhuX, ZengM, et al.A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota. Transl Psychiatry, 2021; 11(1):328; doi: 10.1038/s41398-021-01443-2
30.
LiZ, HuangC, BaoC, et al.Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015; 22(3):256–264; doi: 10.1038/nsmb.2959
31.
ChuC, YuanC, LiuX, et al.Phenylobacterium kunshanense sp. nov., isolated from the sludge of a pesticide manufacturing factory. Int J Syst Evol Microbiol, 2015; 65(Pt 2):325–330; doi: 10.1099/ijs.0.063644-0
32.
HansenTB, JensenTI, ClausenBH, et al.Natural RNA circles function as efficient microRNA sponges. Nature, 2013; 495(7441):384–388; doi: 10.1038/nature11993
33.
YouX, VlatkovicI, BabicA, et al.Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci, 2015; 18(4):603–610; doi: 10.1038/nn.3975
KleavelandB, ShiCY, StefanoJ, et al.A network of noncoding regulatory RNAs Acts in the mammalian brain. Cell, 2018; 174(2):350–362.e317; doi: 10.1016/j.cell.2018.05.022
SongY, ChenM, ZhangY, et al.Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis. Life Sci Alliance, 2023; 6(2):e202201617; doi: 10.26508/lsa.202201617
38.
WangF, LiY, ShenH, et al.Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease. Genome Med, 2024; 16(1):129; doi: 10.1186/s13073-024-01404-6
39.
ZengH-X, QinS-J, WuQ-Z, et al.Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p. J Hazard Mater, 2025; 484:136719; doi: 10.1016/j.jhazmat.2024.136719
40.
Lagunas-RangelFA. Role of circular RNAs in DNA repair. RNA Biol, 2024; 21(1):149–161; doi: 10.1080/15476286.2024.2429945
41.
LiuY, HuaQ, LiM, et al.Circular RNA circNIPBL promotes NNK-induced DNA damage in bronchial epithelial cells via the base excision repair pathway. Arch Toxicol, 2022; 96(7):2049–2065; doi: 10.1007/s00204-022-03297-z
42.
ZhangH, LuW, QiuL, et al.Circ_0025373 inhibits carbon black nanoparticles-induced malignant transformation of human bronchial epithelial cells by affecting DNA damage through binding to MSH2. Environ Int, 2024; 191:109001; doi: 10.1016/j.envint.2024.109001
43.
HuangM-S, LiuJ-Y, XiaX-B, et al.Hsa_circ_0001946 inhibits lung cancer progression and mediates cisplatin sensitivity in non-small cell lung cancer via the nucleotide excision repair signaling pathway. Front Oncol, 2019; 9:508; doi: 10.3389/fonc.2019.00508
44.
QuH, WangY, YanQ, et al.CircCDYL2 bolsters radiotherapy resistance in nasopharyngeal carcinoma by promoting RAD51 translation initiation for enhanced homologous recombination repair. J Exp Clin Cancer Res, 2024; 43(1):122; doi: 10.1186/s13046-024-03049-0
45.
WangY-L, FengL-L, ShiJ, et al.CiRS-7 Enhances the Liquid-liquid Phase Separation of miRISC and Promotes DNA Damage Repair. Nucleus, 2023; 14(1):2293599; doi: 10.1080/19491034.2023.2293599
46.
ZengH, LiM, HuaQ, et al.Circular RNA circ_Cabin1 promotes DNA damage in multiple mouse organs via inhibition of non-homologous end-joining repair upon PM(2.5) exposure. Arch Toxicol, 2021; 95(10):3235–3251; doi: 10.1007/s00204-021-03138-5
47.
ZhengS, TianQ, YuanY, et al.Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer. J Exp Clin Cancer Res, 2023; 42(1):324; doi: 10.1186/s13046-023-02854-3
48.
LinL, HuP, LuoM, et al.CircNOP14 increases the radiosensitivity of hepatocellular carcinoma via inhibition of Ku70-dependent DNA damage repair. Int J Biol Macromol, 2024; 264(Pt 2):130541; doi: 10.1016/j.ijbiomac.2024.130541
49.
LyuF, HuangS, YanZ, et al.CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway. Cell Signal, 2024; 119:111164; doi: 10.1016/j.cellsig.2024.111164
50.
HeZY, ZhuoRG, YangSP, et al.CircNCOR1 regulates breast cancer radiotherapy efficacy by regulating CDK2 via hsa-miR-638 binding. Cell Signal, 2023; 109:110787; doi: 10.1016/j.cellsig.2023.110787
51.
ChenF, WangS, ZengC, et al.Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis. Cell Mol Life Sci, 2023; 80(11):325; doi: 10.1007/s00018-023-04975-6
52.
YangY, FanX, MaoM, et al.Extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Res, 2017; 27(5):626–641; doi: 10.1038/cr.2017.31
53.
ZhouC, MolinieB, DaneshvarK, et al.Genome-Wide Maps of m6A circRNAs identify widespread and Cell-Type-Specific methylation patterns that are distinct from mRNAs. Cell Rep, 2017; 20(9):2262–2276; doi: 10.1016/j.celrep.2017.08.027
54.
XuK, ZhangY, LiJ. Expression and function of circular RNAs in the mammalian brain. Cell Mol Life Sci, 2021; 78(9):4189–4200; doi: 10.1007/s00018-021-03780-3
55.
YuW, ChenD, MaL, et al.EIF4A3-Induced Circ_0059914 Promoted Angiogenesis and EMT of Glioma via the miR-1249/VEGFA Pathway. Mol Neurobiol, 2025; 62(1):973–987; doi: 10.1007/s12035-024-04319-w
56.
WangW, ChengW, WangX, et al.CircFKBP3 absence alleviates oxygen glucose deprivation-induced function loss of human brain microvascular endothelial cells in vitro via governing the miR-766-3p/TRAF3 axis. Int J Neurosci, 2025; 135(1):1–12; doi: 10.1080/00207454.2023.2279506
57.
KuiL, LiZ, WangG, et al.CircPDS5B reduction improves angiogenesis following ischemic stroke by regulating MicroRNA-223-3p/NOTCH2 Axis. Neurol Genet, 2023; 9(3):e200074; doi: 10.1212/nxg.0000000000200074
58.
DilingC, YinruiG, LongkaiQ, et al.Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. Aging (Albany NY), 2019; 11(24):12002–12031; doi: 10.18632/aging.102529
59.
HuangR, ZhangY, HanB, et al.Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy, 2017; 13(10):1722–1741; doi: 10.1080/15548627.2017.1356975
60.
HanB, ZhangY, ZhangY, et al.Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: Implications for cerebral ischemic stroke. Autophagy, 2018; 14(7):1164–1184; doi: 10.1080/15548627.2018.1458173
61.
YangZ, HuangC, WenX, et al.Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion. Mol Ther, 2022; 30(3):1275–1287; doi: 10.1016/j.ymthe.2021.11.004
62.
ZhangY, HuangR, ChengM, et al.Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. Microbiome, 2019; 7(1):116; doi: 10.1186/s40168-019-0733-3
63.
ZhangY, DuL, BaiY, et al.CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Mol Psychiatry, 2020; 25(6):1175–1190; doi: 10.1038/s41380-018-0285-0
64.
XiaoyingG, GuoM, JieL, et al.CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures. J Cell Mol Med, 2020; 24(22):12980–12993; doi: 10.1111/jcmm.15894
65.
HuangR, ZhangY, BaiY, et al.N(6)-Methyladenosine modification of fatty acid amide hydrolase messenger RNA in circular RNA STAG1-Regulated astrocyte dysfunction and depressive-like behaviors. Biol Psychiatry, 2020; 88(5):392–404; doi: 10.1016/j.biopsych.2020.02.018
66.
XieX, SunFK, HuangX, et al.A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis. Aging (Albany NY), 2021; 13(15):19908–19919; doi: 10.18632/aging.203408
67.
HanC, WangS, WangH, et al.Knockdown of circ-ttbk2 inhibits glioma progression by regulating miR-1283 and CHD1. Cancer Manag Res, 2020; 12:10055–10065; doi: 10.2147/cmar.s252916
68.
HuD, ZhangY. Circular RNA HIPK3 promotes glioma progression by binding to miR-124-3p. Gene, 2019; 690:81–89; doi: 10.1016/j.gene.2018.11.073
69.
WangR, ZhangS, ChenX, et al.EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. Mol Cancer, 2018; 17(1):166; doi: 10.1186/s12943-018-0911-0
70.
ZhengH, HuangS, WeiG, et al.CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output. Mol Ther, 2022; 30(11):3477–3498; doi: 10.1016/j.ymthe.2022.06.016
71.
XieBS, WangYQ, LinY, et al.Circular RNA expression profiles alter significantly after traumatic brain injury in rats. J Neurotrauma, 2018; 35(14):1659–1666; doi: 10.1089/neu.2017.5468
72.
HuangXJ, SuGJ, WuCW, et al.Knockdown of rno_circRNA_009194 improves outcomes in traumatic brain injury rats through inhibiting voltage-gated sodium channel Nav1.3. J Neurotrauma, 2022; 39(1–2):196–210; doi: 10.1089/neu.2020.7520
73.
HuangC, SunL, XiaoC, et al.Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1. J Neuroinflammation, 2023; 20(1):39; doi: 10.1186/s12974-023-02716-x
74.
JiangY-J, CaoS-Q, GaoL-B, et al.Circular ribonucleic acid expression profile in mouse cortex after traumatic brain injury. J Neurotrauma, 2019; 36(7):1018–1028; doi: 10.1089/neu.2018.5647
75.
ChenZ, WangH, ZhongJ, et al.Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury. Exp Neurol, 2019; 313:37–48; doi: 10.1016/j.expneurol.2018.12.003
76.
ZhaoRT, ZhouJ, DongXL, et al.Circular ribonucleic acid expression alteration in exosomes from the brain extracellular space after traumatic brain injury in mice. J Neurotrauma, 2018; 35(17):2056–2066; doi: 10.1089/neu.2017.5502
77.
DuM, WuC, YuR, et al.A novel circular RNA, circIgfbp2, links neural plasticity and anxiety through targeting mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after traumatic brain injury. Mol Psychiatry, 2022; 27(11):4575–4589; doi: 10.1038/s41380-022-01711-7
78.
WuC, DuM, YuR, et al.A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury. Free Radic Biol Med, 2022; 178:271–294; doi: 10.1016/j.freeradbiomed.2021.12.007
79.
FuJ, DuM, WuB, et al.CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury. Cell Biosci, 2025; 15(1):21; doi: 10.1186/s13578-025-01353-6
80.
LiZ, LinY, MaoL, et al.Expression characteristics of circular RNA in human traumatic brain injury. Front Neurol, 2022; 13:1086553; doi: 10.3389/fneur.2022.1086553
81.
ZhengP, ShuL, RenD, et al.circHtra1/miR-3960/GRB10 Axis promotes neuronal loss and immune deficiency in traumatic brain injury. Oxid Med Cell Longev, 2022; 2022:3522492; doi: 10.1155/2022/3522492
82.
MaX, WangH, YeG, et al.Hsa_circ_0018401 and miR-127-5p expressions are diagnostic and prognostic markers for traumatic brain injury (TBI) in trauma patients. Neuroscience, 2024; 545:59–68; doi: 10.1016/j.neuroscience.2024.03.010
83.
ChenR, WuW, YangP, et al.Hsa_circ_0009057 can be a novel potential diagnostic biomarker and a therapeutic target for premature brain injury. Neurosci Lett, 2022; 775:136551; doi: 10.1016/j.neulet.2022.136551
84.
DuM, FuJ, ZhangJ, et al.CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model. Clin Transl Med, 2024; 14(11):e70100; doi: 10.1002/ctm2.70100
85.
ChenS, WangX, QianZ, et al.Exosomes from ADSCs ameliorate nerve damage in the hippocampus caused by post traumatic brain injury via the delivery of circ-Scmh1 promoting microglial M2 polarization. Injury, 2023; 54(10):110927; doi: 10.1016/j.injury.2023.110927
86.
ChengYQ, WuCR, DuMR, et al.CircLphn3 protects the blood-brain barrier in traumatic brain injury. Neural Regen Res, 2022; 17(4):812–818; doi: 10.4103/1673-5374.322467
87.
LiH, LuC, YaoW, et al.Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury. Aging (Albany NY), 2020; 12(21):21687–21705; doi: 10.18632/aging.103975
88.
HuangH, JiangNN, LuGW, et al.CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury. Free Radic Biol Med, 2025; 228:44–61; doi: 10.1016/j.freeradbiomed.2024.12.041
89.
DavisCK, BathulaS, HsuM, et al.An antioxidant and Anti-ER stress combo therapy decreases inflammation, secondary brain damage and promotes neurological recovery following traumatic brain injury in mice. J Neurosci, 2022; 42(35):6810–6821; doi: 10.1523/jneurosci.0212-22.2022
90.
DavisCK, BathulaS, JeongS, et al.An antioxidant and anti-ER stress combination therapy elevates phosphorylation of α-Syn at serine 129 and alleviates post-TBI PD-like pathology in a sex-specific manner in mice. Exp Neurol, 2024; 377:114795; doi: 10.1016/j.expneurol.2024.114795
91.
FuJ, ZhouQ, WuB, et al.Protective effects and regulatory pathways of melatonin in traumatic brain injury mice model: Transcriptomics and bioinformatics analysis. Front Mol Neurosci, 2022; 15:974060; doi: 10.3389/fnmol.2022.974060
92.
LiuY, LiuJ, LiuB. Identification of Circular RNA expression profiles and their implication in spinal cord injury rats at the immediate phase. J Mol Neurosci, 2020; 70(11):1894–1905; doi: 10.1007/s12031-020-01586-9
93.
ZhouZB, DuD, ChenKZ, et al.Differential expression profiles and functional predication of circular ribonucleic acid in traumatic spinal cord injury of rats. J Neurotrauma, 2019; 36(15):2287–2297; doi: 10.1089/neu.2018.6366
94.
QinC, LiuCB, YangDG, et al.Circular RNA expression alteration and bioinformatics analysis in rats after traumatic spinal cord injury. Front Mol Neurosci, 2018; 11:497; doi: 10.3389/fnmol.2018.00497
95.
WuR, MaoS, WangY, et al.Differential circular RNA Expression profiles following spinal cord injury in Rats: A temporal and experimental analysis. Front Neurosci, 2019; 13:1303; doi: 10.3389/fnins.2019.01303
96.
SunY, ZhouY, ShiX, et al.CircTYW1 serves as a sponge for microRNA-380 in accelerating neurological recovery following spinal cord injury via regulating FGF9. Cell Cycle, 2021; 20(18):1828–1844; doi: 10.1080/15384101.2021.1962634
97.
CaoJ, PanC, ZhangJ, et al.Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury. BMC Genomics, 2023; 24(1):181; doi: 10.1186/s12864-023-09273-w
98.
WangW, SuY, TangS, et al.Identification of noncoding RNA expression profiles and regulatory interaction networks following traumatic spinal cord injury by sequence analysis. Aging (Albany NY), 2019; 11(8):2352–2368; doi: 10.18632/aging.101919
99.
YaoY, WangJ, HeT, et al.Microarray assay of circular RNAs reveals cicRNA.7079 as a new anti-apoptotic molecule in spinal cord injury in mice. Brain Res Bull, 2020; 164:157–171; doi: 10.1016/j.brainresbull.2020.08.004
100.
YeX, ChenY, WangJ, et al.Identification of circular RNAs related to vascular endothelial proliferation, migration, and angiogenesis after spinal cord injury using microarray analysis in female mice. Front Neurol, 2021; 12:666750; doi: 10.3389/fneur.2021.666750
101.
ChenJ, FuB, BaoJ, et al.Novel circular RNA 2960 contributes to secondary damage of spinal cord injury by sponging miRNA-124. J Comp Neurol, 2021; 529(7):1456–1464; doi: 10.1002/cne.25030
102.
ZhaoY, ChenY, WangZ, et al.Bone marrow mesenchymal stem cell exosome attenuates inflammasome-related pyroptosis via delivering circ_003564 to Improve the recovery of spinal cord injury. Mol Neurobiol, 2022; 59(11):6771–6789; doi: 10.1007/s12035-022-03006-y
103.
WangY, CaiD, KongJ, et al.CircGTF2H2C regulates NLRP3 dephosphorylation via modulating PTPN11 expression in spinal cord injury. Mol Neurobiol, 2025; 62(8):10869–10882; doi: 10.1007/s12035-025-04877-7
104.
ShaoQ, ZhangY, ZhangZ, et al.Downregulation of circular RNA Gla reduced astrocyte inflammatory status by regulating miR-488/MEKK1 levels and promoted functional recovery after spinal cord injury. J Inflamm Res, 2024; 17:7123–7139; doi: 10.2147/jir.s467940
105.
ShaoM, JinM, FeizhouL, et al.Administration of hypoxic pretreated adipose-derived mesenchymal stem cell exosomes promotes spinal cord repair after injury via delivery of circ-Astn1 and activation of autophagy. Int Immunopharmacol, 2025; 152:114324; doi: 10.1016/j.intimp.2025.114324
106.
LiX, KangJ, LvH, et al.CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway. Faseb J, 2021; 35(12):e22014; doi: 10.1096/fj.202100993R
107.
HeR, TangGL, NiuL, et al.Quietness Circ 0000962 promoted nerve cell inflammation through PIK3CA/Akt/NF-κB signaling by miR-302b-3p in spinal cord injury. Ann Palliat Med, 2020; 9(2):190–198; doi: 10.21037/apm.2020.02.13
108.
JiangM, LiY, FanW, et al.Circ-KATNAL1 knockdown reduces neuronal apoptosis and alleviates spinal cord injury through the miR-98-5p/PRDM5 regulatory axis. Mol Biotechnol, 2024; 66(10):2841–2849; doi: 10.1007/s12033-023-00895-9
109.
ShaoM, YeS, ChenY, et al.Exosomes from hypoxic ADSCs ameliorate neuronal damage post spinal cord injury through circ-Wdfy3 delivery and inhibition of ferroptosis. Neurochem Int, 2024; 177:105759; doi: 10.1016/j.neuint.2024.105759
110.
WangX, LiW, HaoM, et al.Hypoxia-treated umbilical mesenchymal stem cell alleviates spinal cord ischemia-reperfusion injury in SCI by circular RNA circOXNAD1/miR-29a-3p/FOXO3a axis. Biochem Biophys Rep, 2023; 34:101458; doi: 10.1016/j.bbrep.2023.101458
111.
LiY, WangB, SunW, et al.Screening the immune-related circRNAs and genes in mice of spinal cord injury by RNA sequencing. Front Immunol, 2022; 13:1060290; doi: 10.3389/fimmu.2022.1060290
112.
QiJ, WangT, ZhangZ, et al.Circ-Ctnnb1 Regulates Neuronal Injury in Spinal Cord Injury through the Wnt/β-Catenin Signaling Pathway. Dev Neurosci, 2022; 44(3):131–141; doi: 10.1159/000521172
113.
YangJ, DongJ, LiH, et al.Circular RNA HIPK2 Promotes A1 Astrocyte Activation after Spinal Cord Injury through Autophagy and Endoplasmic Reticulum Stress by Modulating miR-124-3p-Mediated Smad2 Repression. ACS Omega, 2024; 9(1):781–797; doi: 10.1021/acsomega.3c06679
114.
ZhangS-B, LinS-Y, LiuM, et al.CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain. Nat Commun, 2019; 10(1):4119; doi: 10.1038/s41467-019-12049-0
115.
XieL, ZhangM, LiuQ, et al.Downregulation of ciRNA-Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA-26a-dependent manner. CNS Neurosci Ther, 2023; 29(10):2955–2971; doi: 10.1111/cns.14235
116.
LiuX-D, JinT, TaoY, et al.DHX9/DNA-tandem repeat-dependent downregulation of ciRNA-Fmn1 in the dorsal horn is required for neuropathic pain. Acta Pharmacol Sin, 2023; 44(9):1748–1767; doi: 10.1038/s41401-023-01082-x
117.
TianF, YangJ, XiaR. Exosomes Secreted from circZFHX3-modified Mesenchymal Stem Cells Repaired Spinal Cord Injury Through mir-16-5p/IGF-1 in Mice. Neurochem Res, 2022; 47(7):2076–2089; doi: 10.1007/s11064-022-03607-y
118.
Aquilina-ReidC, BrennanS, Curry-HydeA, et al.Circular RNA expression and interaction patterns are perturbed in amyotrophic lateral sclerosis. Int J Mol Sci, 2022; 23(23):14665.
119.
MatsonKJ, RussDE, KatheC, et al.Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons. Nat Commun, 2022; 13(1):5628.
120.
WuW, ZhangJ, CaoX, et al.Exploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing. Nat Commun, 2022; 13(1):3242.
121.
DongX, BaiY, LiaoZ, et al.Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease. Nat Commun, 2023; 14(1):5327.
122.
RauchmanSH, ZubairA, JacobB, et al.Traumatic brain injury: Mechanisms, manifestations, and visual sequelae. Front Neurosci, 2023; 17:1090672.
123.
QuadriSA, FarooquiM, IkramA, et al.Recent update on basic mechanisms of spinal cord injury. Neurosurg Rev, 2020; 43(2):425–441.
124.
HeAT, LiuJ, LiF, et al.Targeting circular RNAs as a therapeutic approach: Current strategies and challenges. Signal Transduct Target Ther, 2021; 6(1):185.
