Roaccutane (Isotretinoin) and the Risk of Suicide: Case Report and a Review of the Literature and Pharmacovigilance Reports

Claudy A.L. , Rouchouse B. , Boucheron S. , Le Petit J.C. .Treatment of cutaneous lymphoma with Etretinate..Br J Derm. 1983;109:49-56

Cunliffe W.J. , Van De Kerhof Pcm. .Roaccutane Treatment Guidelines: Results of an international survey.Dermatology. 1997;194:351-357

Goulden V. , Layton A.M. , Cunliffe W.J. .Current indications for isotretinoin as a treatment for acne vulgaris.Derm. 1995;190:284-287

Layton A.M. .Long term safety and efficacy of oral isotretinoin in less severe acne.Retinoids Today and Tomorrow. 1996;43:6-7

Bauemfeind J.C. The safe use of vitamin A: a report of the International Vitamin A Consultative Group. Washington, DC: The Nutrition Foundation; 1980:

Kane E.K. Arctic explorations in the years. Philadelphia: Childs & Peterson Pub.; 1853:392 1856.

Halter U. .Der Fall aus der Praxis (224). Akuter exogener reaktionstypus (delirium) nach einnahme von tigason.Schweizerische Rundschau fur Medizin Praxis. 1991;80:883-884

Haupt R. .Acute symptomatic psychosis in vitamin A intoxication (author's translation) [German].Nervenartz. 1977;48:91-95

Gerber A , Raab Ap. , Sobel A.E. .Vitamin A poisoning in adults with description of a case.Am J Med. 1954;16:729-745

Lombaert A. , Carton H. .Benign intracranial hypertension due to hypervita-minosis A in adults and adolescents.Eur Neurol. 1976;14:340-350

Siegel N.J. , Spackman T.J. .Chronic hypervitaminosis A with intracranial hypertension and low cerebrospinal fluid concentration of protein.Clin Pediatr (Phila). 1972;11:580-584

Lee A.G. .Pseudotumor cerebri after treatment with Tetracycline and Isotretinoin.Cutis. 1995;55:165-168

Roytman M. , Frumkin A. , Bohn T.G. .Pseudotumor cerebri caused by Isotretinoin.Cutis. 1988;42:399-400

Bonnetblanc J.M. , Hugon J. , Dumas M. .Intracranial hypertension with etretinate.Lancet. 1983;22:974

Restak R.M. .Pseudotumor cerebri, psychosis, and hypervitaminosis A.J Nerv Ment Dis. 1972;155 (1): 72-75

McCance-Katz E.F. , Price L.H. .Depression associated with vitamin A intoxication.Psychosomatics. 1992;33 (1): 117-118

Stimson W.H. .Vitamin A intoxication in adults: Report of a case with a summary of the literature.New Engl J Med. 1961;265:369-373

Bifulco M.H. .The relation of Vitamin A intake to cerebrospinal fluid pressure: A review.J Mount Sinai Hosp NY. 1957;24:713-719

Elliot R.A. , Dryer C.G. .Hypervitaminosis A: Report of a case in an adult.JAMA. 1965;161:1157-1159

Oliver T.K. , Havener W.H. .Eye manifestations of chronic vitamin A intoxication.Arch Ophthal. 1958;60:19-22

Duke E.E. , Guenther L. .Psychiatric reactions to the retinoids.Can J Derm. 1993;5 (4): 467

Gatti S. , Serri F. .Acute depression from isotretinoin (letter).J Am Acad Derm. 1991;25:132

Bravard P. , Krug M. , Rzeznick J.C. .Isotretinoine et depression: soyons vigilants.Nouv Dermatol. 1993;12:215

Hazen P.G. , Carney J.F. , Walker A.E. , Stewart J.J. .Depression—a side effect of 13-cis-retinoic acid therapy.J Am Acad Derm. 1983;9 (2): 278-279

Meyskens F.L. .Jr. Short clinical reports.J Am Acad Derm. 1982;6:732

Bigby M. , Stern R.S. .Adverse reactions to isotretinoin.J Am Acad Derm. 1988;18:543-552

Scheinman  .Acute Depression from isotretinoin.J Am Acad Derm. 1990;22 (6): 1112-1114

Villalobos D. , Ellis M. , Snodgrass W.R. .Isotretinoin (Accutane)-associated psychosis.Vet Human Toxicol. 1989;31 (4): 131

Byrne A. , Costello M. , Greene E. , Zibin T. .Isotretinoin therapy and depression-evidence for an association.Ir J Psych Med. 1998;15 (2): 58-60

Shapiro L.E. , Knowles S.R. , Shear N.H. .Comparative safety of tetracycline, minocycline and doxycycline.Arch Dermatol. 1997;133:1224-1230

Cotterill J.A. , Cunliffe W.J. .Suicide in dermatological patients.Br J Derm. 1997;137:246-250

32.French Product License Data Sheet. B.I.A.M. 03/03/1997.