Numerous trials have been conducted evaluating the efficacy of ginkgo biloba in memory disorders. The active constituents of ginkgo biloba are antioxidants that scavenge free radicals, which have been implicated in the pathogenesis of memory disorders. These studies suggest that ginkgo biloba in doses up to 120 mg/day when taken for 2 years may halt the progression of the disease for at least six months. The biggest concern of using ginkgo biloba is associated with its effects on platelet activating factor, which may result in bleeding disorders. Additional studies are needed to evaluate ginkgo biloba in combination with other medications.
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References
1.
Sloane Pd..Advances in the Treatment of Alzheimer's Disease.American Family Physician.. 1998;58 (7): 1577-1586
Shimomura T,Mori E,Yamashita H.Cognitive Loss in Dementia with Lewy Bodies and Alzheimer Disease.Archives of Neurology.. 1998;55:1547-1552
4.
Tariot Pn,Schneider L,Porsteinsson Ap..Treating Alzheimer's Disease. Pharmacologic Options Now and in the Near Future.Postgraduate Medicine. 1997;101 (6): 73-90
5.
Thompson Ca..As Patients Embrace Herbal Remedies, Dearth of Scientific Evidence Frustrates Clinicians.American Society of Health-Systems Pharmacists.. 1997;54:2656
6.
Taylor P..Development of Acetylcholinesterase Inhibitors in the Therapy of Alzheimer's Disease.Neurology. 1998;51 (Suppl. 1): S30-S35
7.
Farlow Mr,Evans Rm..Pharmacologic Treatment of Cognition in Alzheimer's Dementia.Neurology.. 1998;51 (Suppl. 1): S36-S44
8.
Cummings Jl..Neuropsychiatric Symptoms in Alzheimer's Disease. Response to Cholinesterase Inhibitor Therapy. Alzheimer's Disease.Management Today. 1998;1 (4): 3-5
9.
Aisen Ps,Davis Kl..The Search for Disease-Modifying Treatment for Alzheimer's Disease.Neurology.. 1997;48 (Suppl. 6): S35-S41
10.
Gillespie Sg..Herbal Drugs and Phytomedicinal Agents.Pharmacy Times. 1997;:53-61
11.
Schmid W..Ginkgo Thrives.Nature. 1997;386:755
12.
Britton J,Kircher T.The Complete Book of Home Herbal Remedies. A Holistic Guide to Understanding and Treating Common Ailments with Herbs. Buffalo, New York: Firefly Books; 1998:
13.
Ginkgo Biloba for Dementia.The Medical Letter. 1998;40 (Issue 1029): 63-64
Gorman C..More Than a Funny Name. Ginkgo, Long Revered in the East, Gets Its First Plug in a U.S. Medical Journal—As an Alzheimer's Drug.Time.. 1997;150 (18):
17.
Skolnick Aa..Old Chinese Herbal Medicine Used for Fever Yields Possible New Alzheimer Disease Therapy.JAMA.. 1997;277 (10): 776
Foster S. GinkgoGinkgo Biloba (Botanical Series 304). Austin, TX: American Botanical Council; 1996:
24.
Williamson Js,Wyandt Cm..Herbal Therapies: The Facts and the Fiction.Drug Topics. 1997;:78-85
25.
Skolnick Aa..Old Chinese herbal Medicine Used for Fever Yields Possible New Alzheimer Disease Therapy.JAMA.. 1997;277 (10): 776
26.
White Hl,Scates Pw,Cooper Br..Extracts of Ginkgo Biloba Leaves Inhibit Monoamine Oxidase.Life Sciences.. 1996;58 (16): 1315-1321
27.
Koltai M,Hosford D,Guinot P.Platelet Activating Factor (PAF). A Review of Its Effects, Antagonists and Possible Future Clinical Implications (Part I).Drugs.. 1991;42 (1): 9-29
28.
Smith Pf,Maclennan K,Darlington Cl..The Neuroprotective Properties of the Ginkgo Biloba Leaf: A Review of the Possible Relationship to Platelet-Activating Factor (PAF).Journal of Ethnopharmacology. 1996;:50
29.
Moreau Jp,Eck J,McCabe J.Absorption, distribution, élimination de l'extrait marqué de feuilles de Ginkgo biloba chez le rat.Presse Med.. 1986;15:1458-1461
30.
Le Bars Pl,Katz Mm,Berman N.A Placebo-Controlled, Double-Blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia.JAMA.. 1997;278:1327-1332
31.
Kleijnen J,Knipschild P..Ginkgo Biloba for Cerebral Insufficiency.British Journal of Clinical Pharmacology.. 1992;34:352-358
