Phenytoin Monitoring in the Intensive Care Unit

Abstract

Phenytoin has been used extensively in the neurological and neurosurgical settings since its introduction in 1938. Despite the fact that alternative agents exist, including a whole series of newer agents, phenytoin is still considered one of the most effective, relatively nontoxic anticonvulsant therapies currently available. Unfortunately, however, the pharmacokinetics and pharmacodynamics of this drug are complex and often confuse the pharmacist and physician team, resulting in suboptimal or unacceptably high serum concentrations. This was exactly the case in our institution up until 3 years ago, when a major pharmacy-initiated education and dosing service program was implemented. We review the basic phenytoin monitoring guidelines used in our institution, which are substantiated by the current literature and by personal experience.