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References
1.
Astava
A
Hunter
JM
, Reversal of neuromuscular block . Br J Anaesth . 2009 ;103 (1 ):115 –129 .
2.
McLean
DJ
Diaz-Gil
D
Farhan
HN
. Dose-dependent association between intermediate-acting neuromuscular-blocking agents and postoperative respiratory complications . Anesthesiology . 2015 ;122 (6 ):1201 –1213 .
3.Eclat Pharmaceuticals . Bloxiverz® [package insert] . Chesterfield , MO : Eclat Pharmaceuticals ; 2013 .
4.
Sasaki
N
Meyer
M
Malviya
A
. Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes . Anesthesiology . 2014 ;121 (5 ):959 –968 .
5.
Mantegazza
R
Bonanno
S
Camera
G
. Current and emerging therapies for the treatment of myasthenia gravis . Neuropsychiatr Dis Treat . 2011 ;7 :151 –160 .
6.US Food and Drug Administration , Center for Drug Evaluation and Research . Neostigmine NDA Clinical Review 204078 . 2013 . https://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/UCM361414.pdf. Accessed May 15, 2017 .
7.
FDA Issues Revised Guidance on Marketed Unapproved Drugs
. 2014 . http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/EnforcementActivitiesbyFDA/SelectedEnforcementActionsonUnapprovedDrugs/ucm270831.htm. Accessed February 3, 2017 .
8.
Greenberg
S
. The neostigmine shortage: a clinical conundrum with few drug alternatives . The Official Journal of the Anesthesia Patient Safety Foundation—APSF Newsletter . 2015 . http://www.apsf.org/newsletters/html/2015/Oct/04_Neostigmine.htm. Accessed January 31, 2017 .
9.Flamel Technologies Announces Acquisition of Éclat Pharmaceuticals . 2014 . http://www.businesswire.com/news/home/20120314006675/en/Flamel-Technologies-Announces-Acquisition-%C3%89clat-Pharmaceuticals. Accessed April 10, 2017 .
10.Flamel Technologies Completes Cross-Border Merger with Avadel Pharmaceuticals (AVDL) Becoming Surviving Public Company . 2017 . https://www.streetinsider.com/Corporate+News/Flamel+Technologies+Completes+Cross-Border+Merger+with+Avadel+Pharmaceuticals+(AVDL)+Becoming+Surviving+Public+Company/12383533.html. Accessed April 10, 2017 .
11.Flamel Technologies Announces FDA Approval of Bloxiverz . 2013 . http://www.marketwired.com/press-release/flamel-technologies-announces-fda-approval-of-bloxiverz-nasdaq-flml-1797175.htm. Accessed February 28, 2017 .
12.
Ronny
H.
Flamel Technologies: Bloxiverz Competition to Cease Marketing . 2014 . http://seekingalpha.com/article/2306535-flamel-technologies-bloxiverz-competition-to-cease-marketing. Accessed February 28, 2017 .
13.NORC at the University of Chicago . Final Report: Trends in Hospital Inpatient Drug Costs: Issues and Challenges. Presented to American Hospital Association . Chicago, IL : NORC at the University of Chicago ; 2016 .
14.
Langreth
R
. 2,000% Drug Price Surge Is a Side Effect of FDA Safety Program . 2015 . www.bloomberg.com/news/articles/2015-10-06/2-000-drug-price-surge-is-a-side-effect-of-fda-safety-program.
15.
Wheeler
M
. Current Drug Shortages - Neostigmine Methylsulfate Injection . 2015 . American Society of Health-System Pharmacists http://www.ashp.org/menu/DrugShortages/ResolvedShortages/Bulletin.aspx?id=1150. Accessed May 15, 2017 .
16.
Rubenfire
A
. Drug price hikes may be hitting hospitals harder than consumers . 2016 . http://www.modernhealthcare.com/article/20161011/NEWS/161019988. Accessed February 28, 2017 .
17.
Kounang
N
. Why pharmaceuticals are cheaper abroad . 2015 . http://www.cnn.com/2015/08/28health/us-pays-more-for-drugs/. Accessed March 1, 2017 .
18.Sandoz Inc. Regonol® [package insert] . Princeton , NJ : Sandoz Inc ; 2009 .
19.
Bevan
D
Donati
F
Kopman
AF
. Reversal of neuromuscular blockade . Anesthesiology . 1992 ;77 (4 ):785 –805 .
20.Mylan Institutional Inc. Enlon® [package insert] . Rockford , IL : Mylan Institutional Inc ; 2013 .
21.
Mirakhur
R
Gibson
F
Lavery
G
. Antagonism of vecuronium induced neuromuscular blockage with edrophonium or neostigmine . Br J Anaesth . 1987 ;59 :473 –477 .
22.DRUGDEX® system (electronic version) . Greenwood Village, Colorado : Truven Health Analytics . http://www.micromedexsolutions.com/. 2017 .
23.AmerisourceBergen Corporation Customer Ordering Portal . 2017 . https://passport.amerisourcebergen.com/irj/portal/Bridion/Pricing. Accessed May 15, 2017 .
24.Merck & Co. Inc. Bridion® [package insert] . Whitehouse Station , NJ : Merck & Co ; 2016 .
25.
Kovac
A
. Sugammadex: a selective relaxant binding agent for neuromuscular block reversal . Formulary . 2009 ;44 :13 –21 .
26.Pharmaceutical Compounding—sterile preparations (General Chapter <797>) . In: The United States Pharmacopeia, 39th Review, and the National Formulary . 34th ed . Rockville, MD : The United States Pharmacopeial Convention ; 2016 :626 –670 .
27.
Karen
B
. In operating room, a switch to prefilled syringes pays off . Anesthesiology News . 2013 . http://www.anesthesiologynews.com/PRN-/Article/03-13/In-Operating-Room-A-Switch-to-Prefilled-Syringes-Pays-Off/22707/ses=ogst. Accessed January 26, 2017 .
