Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed drugs throughout the world for pain relief. Although the adverse effects of NSAIDs to the liver are well known, flurbiprofen-induced liver cholestasis is extremely rare. Herein, we present a patient with prolonged icterus that is associated with the use of flurbiprofen without causing ductopenia.
BarafHSFuentealbaCGreenwaldM. Gastrointestinal side effects of etoricoxib in patients with osteoarthritis: results of the etoricoxib versus diclofenac sodium gastrointestinal tolerability and effectiveness (EDGE) trial. J Rheumatol. 2007;34(2):408–420.
2.
FosbølELGislasonGHJacobsenS. Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort study. Clin Pharmacol Ther. 2009;85(2):190–197.
3.
BessoneF. Non-steroidal anti-inflammatory drugs: what is the actual risk of liver damage?World J Gastroenterol. 2010;16(45):5651–5661.
4.
Ruiz-RebolloMLDelgado-FontanedaETestillano-TarreroM. Cholestasis caused by hypersensitivity to flurbiprofen. Rev Esp Enferm Dig. 1992;82(2):130–131.
5.
KotowskiKEGraysonMF. Side effects of non-steroidal anti-inflammatory drugs. Br Med J (Clin Res Ed). 1982;285(6338):377.
6.
LacroixILapeyre-MestreMBagheriH; Club de Reflexion des cabinets de Groupe de Gastro-Enterologie (CREGG); general practitioner networks. Nonsteroidal anti-inflammatory drug-induced liver injury: a case–control study in primary care. Fundam Clin Pharmacol. 2004;18(2):201–206.
7.
ReubenAKochDGLeeWM; Acute Liver Failure Study Group. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010;52(6):2065–2076.
8.
NaranjoCABustoUSellersEM. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239–245.
9.
WatkinsPBSeligmanPJPearsJS. Using controlled clinical trials to learn more about acute drug induced liver injury. Hepatology. 2008;48(5):1680–1689.
10.
AlamIFerrellLDBassNM. Vanishing bile duct syndrome temporally associated with ibuprofen use. Am J Gastroenterol. 1996;91(8):1626–1630.
MunozSJMartinez-HernandezAMaddreyWC. Intrahepatic cholestasis and phospholipidosis associated with the use of trimethoprim-sulfamethoxazole. Hepatology. 1990;12(2):342–327.