Forensic urine drug testing (FUDT) is a tool of many employers to assess drug use in employees. Collegiate and professional sports test for banned substances. Immunoassays are often the screening test. Gas chromatography/mass spectrometry is the confirmatory test. Numerous foods and medications interfere with test results. Safeguards in FUDT include chain of custody procedures, certification of laboratories and personnel, cutoff values, quality assurance and quality control procedures, and medical review officers. Breath analysis is used in drunk-driving cases. Blood and hair can also be analyzed for substances of abuse. Pharmacists can be an asset in drug testing issues.
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References
1.
Liska, K.1997. " Personal Drug Testing." Drugs and the Human Body5th edition. Upper Saddle River, NJ: Prentice Hall, Inc.
2.
Mandatory Guidelines for Federal Workplace Drug Testing Programs. Substance Abuse and Mental Health Services Administration.
3.
Clarkson, E.D., Lesser, D. and B.D. Paul.1998. "Effective GC/MS procedure for detecting iso-LSD in urine after base-catalyzed conversion to LSD." Clin Chem.44 (2): 287-292.
4.
Ambrose, P.J.1997. "Doping Control in Sports—A Perspective from the 1996 Olympic Games." Am. J. Health-Syst. Pharm.54 (9): 1053-1057.
5.
Cook, R.F., Hersch, R.K, and T.L. McPherson.1999. "Drug Assessment Methods in the Workplace." Drug Testing Technology: Assessment of Field Applications. New York, CRC Press.
6.
Vogl, W.F. and D.M. Bush.1994. Medical Review Officer Manual for Federal Workplace Drug Testing Programs. Substance Abuse and Mental Health Services Administration.
7.
Dasgupta, A., Mahle C., and J. McLemore.1996. "Elimination of fluconazole interference in gas chromatography/mass spectrometric confirmation of benzoylecgonine, the metabolite of cocaine using pentafluoropropionyl derivative." J Forensic Sci.41 (3): 511-513.
8.
Warner, A.1989. " Interference of Common Household Chemicals in Immunoassay Methods for Drugs of Abuse." Clin. Chem.35 (4): 648-651.
9.
Hayner G.N.Drugs of Abuse Testing. Basic Skills in Interpreting Laboratory Data2nd edition. American Society of Health-System Pharmacists . Bethesda1996.
10.
Anderson, P.D.1999. "Forensic Aspects of Drug Interactions, Part I" The Forensic Examiner.8 (9 & 10): 14-17.
11.
Rupp, M.T.1988. "What the Pharmacist Should Know About Urine Testing in the Workplace ." American Pharmacy. NS28 (7).
12.
Eskridge, K.D. and S.K. Guthrie.1997. "Clinical Issues Associated with Urine Testing of Substances of Abuse." Pharmacotherapy . 17 (3): 497-510.
13.
Fitzgerald R.L., Ramos, J.M., Bogema, S.C. , and A. Poklis.1988 . " Resolution of Methamphetamine Stereoisomers in Urine Drug Testing: Urinary Excretion of R(-)-methamphetamine Following Use of Nasal Inhalers." J. of Anal. Toxicol..12: 255-259.
14.
Cody, J.T. and S. Valtier.1996. "Detection of Amphetamine Following Administration of Fenproporex." J. of Anal Toxicol.20: 425-431.
15.
Hayes, L.W., Krasselt, W.G., Mueggler, P.A., 1987. "Concentration of Morphine and Codeine in Serum and Urine After Ingestion of Poppy Seeds," Clin Chem33(6):806-808.
16.
Meadway, C., George, S., Braithwaite, R., 1998, "Opiate Concentrations Following the Ingestion of Poppy Seed Products—Evidence for "the Poppy Seed Defense," Forensic Sci Int, 96(1):29-38.
17.
Lehmann, T., Sager, F., Brenneisen, R., 1997. "Excretion of Cannabinoids in Urine After Ingestion of Cannabis Seed Oil," J Anal Toxicol21(5):373-375.
18.
Costantino, A., Schwartz, R.H., Kaplan, P. , 1997. " Hemp Oil Ingestion Causes False Positive Urine Tests for Delta 9-Tetrahydrocannabinol Carboxylic Acid," J Anal Toxicol21(6):482-485.
19.
Cone, E.J, et al. 1995. "Passive Inhalation of Cocaine," J. Anal Toxicol, (19)6:399-411.
Heidemann, S.M., Goetting, M.G., 1990. "Passive Inhalation of Cocaine by Infants," Henry Ford Hospital Med J., (38)4:252-254.
22.
Lustbader, A.S. et al. 1998. "Incidence of Passive Exposure to Crack/Cocaine and Clinical Findings in Infants Seen in Outpatient Service," Pediatrics , 102(1):5.
23.
Le, S.D., et al.1992. "Occupational Exposure to Cocaine Involving Crime Lab Personnel," Journal of Forensic Sciences, (37) 4: 959-968.
24.
Cone, E.J., et al.1987 . "Passive Inhalation of Marijuana Smoke: Urinalysis and Room Air Levels of Delta-9-Tetrahydrocannibinol," Journal of Anal Toxicology, (11): 89-96.
25.
Perez-Reyes, M., et al., 1983. "Passive Inhalation of Marijuana Smoke and Urinary Excretion of Cannabinoids," Clin Pharmacol Ther.34(1): 36-41.
26.
Morland, J., et al.1985 . "Cannabinoids in Blood and Urine After Passive Inhalation of Cannabis Smoke," J Forensic Sci, 30(4):997-1002.
27.
Cone, E.J., Johnson R.E., 1986. "Contact Highs and Urinary Cannabinoid Excretion After Passive Exposure to Marijuana Smoke," Clin Pharmacol Ther.40(3):247-56.
28.
Freeman, A.S., Martin, B.R.1983, "Interactions Between Phencyclidine and Delta 9tetrahydrocannabinol in Mice Following Smoke Exposure," Life Sci32:1081-1089.
29.
Meng, Y. et al., 1996 , "Pharmacological Potency and Biodisposition of Phencyclidine via Inhalation Exposure in Mice," Drug Alcohol Depend, (43)1-2:13-22.
30.
Pitts, F.N. et al., 1981 , "Occupational Intoxication and Long-Term Persistence of Phencyclidine (PCP) in Law Enforcement Personnel," Clin Toxicol18(9):1015-1020.
31.
Aniline, O., et al., 1980 , "Incidental Intoxication with Phencyclidine," J. Clin Psychiatry41(11): 393-394.
32.
Caplan, Y.H.1996. "Blood, Urine, and Other Fluid and Tissue Specimens for Alcohol Analysis." Medicolegal Aspects of Alcohol3rd edition. Tucson, AZ: Lawyers & Judges Publishing Company .
33.
Harding, P.1996. "Methods of Breath Analysis." Medicolegal Aspects of Alcohol3rd edition. Tucson, AZ: Lawyers & Judges Publishing Company.
Overstreet-Price K., Huff, P.S., Isetts, B.J. , and M.A. Goldwire.1995. "University-based Sports Pharmacy Program." Am. J. Health-Syst. Pharm.52: 302-309.
