Plasticizers in Renal Failure: Aspects of Metabolism and Toxicity

Gulbring B. The use of plastics in blood transfusion equipment with special regard to toxicity problems. Vox Sang 1964; 9: 513–59.

Ljunggren L. Plasticizer migration from blood lines in hemodialysis. Artif Organs 1984; 8: 99–102.

Schmid P. , Schlatter C.H. Excretion and metabolism of (ethylhexyl)phthalate in man. Xenobiotica 1985; 15: 251–6.

Poilack G.M. , Buchanan J.F. , Slaughter R.L. , Kohii R.K. , Shen D.D. Circulating concentrations of di(2-ethylhexyl)phthalate and its deesterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis. Toxicol Appl Pharmacol 1985; 79: 257–67.

Gibson T.P. , Briggs W.A. , Boone B.J. Delivery of di(2-ethylhexyl) phthalate to patients during hemodialysis. J Lab Clin Med 1976; 87: 519–24.

Peck C.C. , and Albro P.W. Toxic potential of the plasticizer di(2ethyihexyl)phthalate in the context of its disposition and metabolism in primates and man. Environ Health Perspect 1982; 45: 11–7.

Dirven HAAM , van den Broek P.H.H. , Arens A.M.M. Metabolites of the plasticizer di(2-ethylhexyl)phthalate in urine samples of workers in polyvinylchloride processing industries. Int Arch Occup Environ Health 1993; 64: 549–54.

Nassberger L. , Arbin A. , Ostelius J. Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis. Nephron 1987; 45: 286–90.

Chen W.S. , Kerkay J. , Pearson K.H. Tissuebis(2-ethylhexyl) phthalate levels in uremic subjects. Analytical Letters 1979; 12(B15): 1517–35.

Woodward K.N. Phthalate Esters: Toxicity and metabolism. Volume 1, Chapter 1, S.1. Boca Raton, Florida: CRC Press Inc., 1988.

Reddy J.K. , Laiwani N.D. Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC CritRev Toxicol 1984; 12: 1–58.

Tomita I. , Nakamura Y. , Yagi Y. , Tutikawa K. Teratogenicitylfeto toxicity of DEHP in mice. Environ Health Perspect 1982; 45: 71–6.

Kluwe W.M. , McGonnell E.E. , Huff J.E. , Haseman J.K. , Douglas J.F. , Hartwell W.V. Carcinogenicity testing of phthalate esters and related compounds by the National Toxicology Program and the National Cancer Institute. Environ Health Perspect 1982; 45: 129–33.

Crocker J.F.S. , Safe S.H. , Acott P. Effects of chronic phthalate exposure to the kidney. J Toxicol Environ Health 1988; 23: 433–44.

Oishi S. , Hiraga K. Testicular atrophy induced by phthalate acid esters: effect on testosterone and zinc concentrations. Toxicol Appl Pharmacol 1980; 53: 35.

Labow R.S. , Barry Y.A. , Tocchi M. , Keon W.J. The effect of mono(2-ethyihexyl)phthalate on an isolated perfused rat heart-lung preparation. Environ Health Perspect 1990; 89: 189–93.

Fracasso A. , Coli U. , Landini S. Plasticizer from plastic devices: effect on peritoneal membrane. Peritoneal dialysis. In: La Greca G. , Chiaramonte S. , Fabris A. , Feriani M. , and Ronco C. , eds. Peritoneal dialysis. Milan: Wichtig, 1988; 57–60.

Hillman L.S. , Goodwin S.L. , Sherman W.R. Identification and measurement of plasticizer in neonatal tissues after umbilical catheters and blood products. N Engl J Med 1975; 292: 381–6.

Mettang T. , Fritz P. , Weber J. , Machieidt C. , Hobel E. , Kuhlmann U. Uremic pruritus in patients on hemodialysis or Continuous Ambulatory Peritoneal Dialysis (CAPD). The role of plasma histamine and skin mast cells. Clin Nephrol 1990; 34: 136–41.

Mettang T. , Fischer F.P. , Kuhlmann U. Urämischer Pruritus. Pathophysiologische und therapeutische Aspekte. Übersichtsarbeit. Dtsch Med Wschr 1996; 121: 1025–31.

Mallette F.S. , von Haam E. Studies on the toxicity and skin effects of compounds used in the rubber and plastics industries. Arch Ind Hyg Occup Med 1952; 6: 231–40.

Sneddon E.B. Dermatitis from dibutyl phthalate in an aerosol antiperspirant and deodorant. Contact Derm Newsl 1972; 308.

Neumiiller O.A. Phthalsaure. In: Neumdifer O.A. , ed. Stuttgart: W. Keller & Co., 1985; 3200–1.

Mettang T. , Thomas S. , Kiefer T. Uremic pruritus and the exposure to di(2-ethylhexyl)phthalate (DEHP) in hemodialysis patients. Nephrol Dial Transplant

Duwe A.K. , Vas S.I. , Weatherhead J.W. Effects of the composition of peritoneal dialysis fluid on chemiluminescence, phagocytosis, and bactericidal activity in vitro. Infect Immun 1981; 33: 130–5.

Holmes C.J. Biocompatibility of peritoneal dialysis solutions (Editorial). Pent Dial Int 1993; 13: 88–94.

Liberek T. , Topley N. , Jorres A. , Coles G. , Gahl G.M. , Williams J.D. Peritoneal dialysis fluid inhibition of phagocyte function. Effects of osmolality and glucose concentration. J Am Soc Nephrol 1993; 3: 1508–15.

Kjellstrand P. , Martinson E. , Wieslander A. , Holmquist B. Development of toxic degradation products during heat sterilization of glucose-containing fluids for peritoneal dialysis: influence of time and temperature. Perit Dial Int 1995; 15: 26–32.

Fischer F.P. , Schenk U. , Kiefer T. In vitro effects of bicarbonate- versus lactate buffered Continuous Ambulatory Peritoneal Dialysis fluids on peritoneal macrophage function. Am J Kidney Dis 1995; 26: 924–33.

Lewis S. , Holmes C. Host defense mechanisms in the peritoneal cavity of continuous ambulatory peritoneal dialysis patients. Perit Dial Int 1991; 11: 14–21.

Topley N. What is the ideal technique for testing the biocompatibility of peritoneal dialysis solutions? Perit Dial Int 1995; 15(Suppl): 101–5.

Fischer F-P , Machieidt C. , Rettenmeier A.W. , Kuhlmann U. , Mettang T. Plasticizers and inhibition of leucocyte function in vitro. Perit Dial Int (submitted).

Winberg L.D. , Badr M.Z. Mechanism of phthalate-induced inhibition of hepatic mitochondrial beta-oxidation. Toxicol Lett 1995; 76(1): 63–9.

Minkenberg L. , Ferber E. Lucigenin-dependent chemiluminescence as a new assay for NAD(P)H-oxidase activity in particulate fractions of human polymor-phonuclear leukocytes. J Immunol Methods 1984; 71: 61–7.