Functional activity of peritoneal macrophages of 50 patients with end-stage renal failure on intermittent peritoneal dialysis (IPD) and of 30 control subjects with normal renal function was determined. Phagocytosis of latex particles by macrophages of dialyzed patients was significantly lower as compared with the controls. Further depression of the phagocytic activity was observed during bacterial peritonitis. Macrophages from the dialyzed patients also showed nonsignificantly decreased functional expression of Fc receptors (FcR) and increased spontaneous nitro blue tetrazolium (NeT) reduction.
SulowiczW.Usefulness of light microscopic and Cytur test estimation of peritoneal dialysate in early diagnosis of peritonitis.Int Urol Nephrol1990; 22: 189–97.
2.
VerbrughH.A., KeanneW.F., HoidalJ.R.Peritoneal macrophages and opsonins: Antimicrobial defense in patients on chronic peritoneal dialysis.J Infect Dis1983; 147: 1018–29.
3.
GentileG.M., FellinG., TorpisR.Role of connecting system for peritonitis prevention in CAPD: Report of the Italian CAPD Study Group (Abstract).Nephrol Dial Transplant1986; 1: 114.
4.
VasS.I.Can advances in connector technology reduce peritonitis in CAPD?Perit Dial Bull1985; 5: 5–6.
5.
McGregorS.J., BrockJ.H., BriggsJ.D.Relationship of lgG, C3 and transferin with opsonisis and bacteriostatic activity of peritoneal fluid from CAPD patients and the incidence of peritonitis.Nephrol Dial Transplant1987; 2: 551–6.
6.
SombolosK., VasS., RifkinO.Propionibacteria isolates and asymptomatic infections of the peritoneal effluent in CAPD patients.Nephrol Dial Transplant1986; 1: 175–8.
7.
CichockiT., HanickiZ., SulowiczW.Output of peritoneal cells into peritoneal dialysate. Cytochemical and functional studies.Nephron1983; 35: 175–82.
8.
McGregorS.J., BrockJ.H., BriggsJ.D.Bactericidal activity of peritoneal macrophages from continuous ambulatory dialysis patients.Nephrol Dial Transplant1987; 2: 104–8.
9.
Van BronswijkH., BeelenR.H., VerbrughH.A.Recurrent peritonitis in CAPD: Survival and growth of bacteria within human mononuclear phagocytes as a possible mechanism (Abstract).Nephrol Dial Transplant1986; 1: 113.
10.
SulowiczW., CichockiT., HanickiZ.Changes in activity of selected lysosomal enzymes in peritoneal macrophages of renal failure patients on peritoneal dialysis.Perit Dial Int1989; 9: 313–7.
11.
KowalczykD., RuggieroI., ZembalaM.Monocyte regulation of lymphokine production in cancer patients.J Clin Lab Immunol1986; 19: 37–42.
12.
KumasaiK., ItohK., HinumaS.Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation.J Immunol Methods1979; 29: 17–23.
13.
UraczW., Pituch-NoworolskaA., ZembalaM.“Activated” monocytes in gastric cancer patients. I. Increased Fc receptor expression, antibody-dependent cellular cytotoxicity and NBT reduction.J Cancer Res Clin Oncol1982; 104: 181–90.
14.
SulowiczW.Random migration of leukocytes and phagocytic activity of neutrophils in patients with cancer of gastrointestinal tract at different clinical stages.Rev Esp Oncol1983; 30: 317–21.
15.
AbrutynE., SolomonsN.W., ClairL.S.Granulocyte function in patients with chronic renal failure: Surface adherence, phagocytosis and bactericidal activity in vitro.J Infect Dis1977; 4: 1–8.
16.
ChretinJ.S., GaragusiV.F.Phagocytosis and nitroblue tetrazolium reduction in uremia.Experientia1973; 29: 612–3.
17.
GuckianJ.C., KarrhL.R., CopelandJ.L.Phagocytosis by polymorphonuclear leukocytes in patients with renal failure on chronic hemodialysis.Tex Rep Biol Med1971; 29: 193–8.
18.
BurlesonR.L.Reversible inhibition of phagocytosis in anephric uremic patients.Surg Forum1973; 24: 75–7.
19.
HirabayashiY., KobayashiT., NishikawaA.Oxidative metabolism and phagocytosis of polymorphonuclear leukocytes in patients with chronic renal failure.Nephron1988; 49: 305–12.
20.
KorcakovaL., HolubM., BlahaJ.Increased phagocytosis of neutrophil granulocytes in patients on chronic hemodialysis (Abstract). 20th Congress EDTA London 1983: 70.
21.
UrbanitzD., NoldenH.P., FechnerI.Zur Monocyte-Function bei Kranken mit terminaler Niereninsuffizienz.Klin Wochenschr1975; 53: 59–65.
22.
RingoirS., Van LoyL., Van de HeyningP.P.Impairment of phagocytic activity of macrophages as studied by the skin window test in patients on regular hemodialysis treatment.Clin Nephrol1975; 4: 2347.
23.
GoldsteinC.S., BomalskiJ.S., ZurierR.B.Analysis of peritoneal macro phages in continuous ambulatory peritoneal dialysis.Kidney Int1984; 26: 733–40.
24.
KeaneW.F., ComtyC.M., VerburghH.A.Opsonic deficiency of peritoneal dialysis effluent in continuous ambulatory peritoneal dialysis.Kidney Int1984; 25: 53944.
25.
KeaneW.F., PetersonP.K.Host defense mechanisms of the peritoneal cavity and continuous ambulatoryperitoneal dialysis.Perit Dial Bull1984; 4: 122–7.
26.
ColesG.A., AlobaidiH.M.M., TopleyN.Opsonic activity of dialysis effluent predict those at risk of Staphylococcus epidermidis peritonitis.Nephrol Dial Transplant1987; 2: 359–63.
27.
CecchinE., De MarchiS., De PaoliP.Defective peritoneal polymorphonuclear function in patients on CAPD. Effects of some divalent ions and fibronectin (Abstract).Perit Dial Bull1984; 4 Suppl: 12.
28.
GoldsteinC.S., NielsonE.G., PolinR.A.Decreased fibronectin secretion by peritoneal macro phages is associated with higher incidence of peritonitis among continuous ambulatory dialysis (CAPD) patients (Abstract).Kidney Int1985; 27: 179.
29.
PertosG., MastrolittiG., FracasseA.Effect of fibronectin on Fc and C3b receptors mediated phagocytosis by peripheral blood monocytes of uremic patients (Abstract).Nephrol Dial Transplant1987; 2: 398.
30.
BlumenkrantzM.J., GahlG.H., KoppleJ.D.Protein loss during peritoneal dialysis.Kidney Int1981; 19: 593–602.
31.
LamperiS., CarozziS.Interferons, peritoneal macrophages and peritonitis in CAPD patients (Abstract).Perit Dial Bull1987; 7 Suppl: 46.
32.
SulowiczW.Phagocytic activity of neutrophils from the peritoneal dialysate of patients with chronic renal failure treated by intermittent peritoneal dialysis.Folia Haematol1990; 117: 325–30.
33.
NewmanS.L., MussonR.A., HensonM.P.Development of complement receptors during in vitro maturation on human monocytes into macrophages.J Immunol1980; 125: 2236–45.
34.
JungiT.W., HaffenS.Quantitative assessment Fc receptor expression and function during in vitro differentiation of human monocytes to macrophages.Immunology1986; 58: 131–7.
35.
WuestD., CraneR., RinehardJ.J.Enhancement of Fc receptor function during human monocyte differentiation in vitro.J Reticuloendothel Soc1981; 30: 14752.
36.
DoughertyG.J., DoughertyS.T., McBrideW.H.Monocyte heterogeneity. In: Human Monocytes.ZembalaM., and AshersonG.L., eds. Academic Press, 1989: 71–8.
37.
RaffH.V., PickerL.J., StoboJ.D.Macrophage heterogeneity in man. A subpopulation of HLA-DR bearing macrophages required for antigen-induced T cell activation also contains stimulators for autologous-reactive T cells.J Exp Med1980; 152: 581–93.
