Ultrafiltration and solute transport during 60-min peritoneal dialyses of normal rabbits with intraperitoneal administration of phosphatidylcholine were compared to control values. The ultrafiltration rate of 0.27 mLIKglmin did not increase when phosphatidylcholine was added. This agent had no effect on the ultrafiltration coefficient, sodium mass transport or solute clearances. Previously reported beneficial results with this agent could be due to repletion of a deficiency or an effect of the organic solvent. More studies of safety and efficacy of phosphatidylcholine are warranted before widespread clinical use.
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2.
Di PaoloN., BuoncristianiU., GaggiottiE., CapotondoL., De MiaM.Improvement of impaired ultrafiltration after addition of phosphatidylcholine in patients on CAPD.Perit Dial Bull.1986; 6: 44–45.
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MaherJ.F., HirszelP., LasrichM.An experimental model for study of pharmacologic and hormonal influences on peritoneal dialysis.Contrib Nephrol.1979; 17: 131–138.
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MaherJ.F., BennettR.R., HirszelP., ChakrabartiE.The mechanism of dextrose-enhanced peritoneal transport rates.Kidney Int.1985; 28: 16–20.
5.
MaherJ.F., HirszelP., ChakrabartiE., BennettR.R.Increased peritoneal ultrafiltration due to amphotericin B-augmented sodium transport. In: MaherJ.F., WinchesterJ.F., eds. Frontiers in peritoneal dialysis, Proc III Int Symp Peritoneal Dialysis.New York: Field Rich and Associates: 1986: 106–109.
