Abstract
Fifteen patients receiving continuous ambulatory peritoneal dialysis (CAPD) were given 10 mL of a dietary fish oil rich in omega-3 fatty acids (MaxEPA) b.i.d. for eight weeks without other dietary manipulation. Fasting lipids, vitamins A and E, and glucose were measured at 0, 4, and 8 weeks, and again at 4 and 8 weeks after the cessation of treatment.
Basal serum triglyceride concentrations were raised, and fell by 29% (p < 0.005) with treatment, returning to baseline values over the washout period. The fall in triglyceride during treatment correlated with the initial value (As = 0.57; p < 0.05). Total, HDL and LDL cholesterol, apolipoprotein A, vitamin A, glucose, lean body mass, and dietary fat/CHO intake were unchanged throughout. Apolipoprotein B concentrations tended to rise during the first half of treatment but fell thereafter. Vitamin E concentrations rose significantly during supplementation and fell after withdrawal (p < 0.001 for both).
Supplementation with dietary fish oil significantly reduced hypertriglyceridemia. Its long-term use might be accompanied by beneficial effects on the excess cardiovascular morbidity seen in patients on CAPD.
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