We studied the absorption of i.p. loading dose of vancomycin (30 mg/kg of body weight) in five continuous ambulatory peritoneal dialysis (CAPD) patients, both at the time of peritonitis and after its resolution. Mean vancomycin absorption after 6 h of i.p. dwell was 74% from inflamed and 51% from noninflamed peritoneum. Mean peritoneal absorption half-life of vancomycin was 3.2 and 7.2 h in the inflamed vs. non inflamed peritoneum, respectively.
BastaniB., FreerK.E., WesterveltFBJr.. Treatment of peritonitis with two intraperitoneal doses of vancomycin in continuous ambulatory peritoneal dialysis patients (Abstr.).Kidney Int.1986; 29: 229.
2.
BastaniB., FreerK.E., ReadD.Treatment of grampositive peritonitis with two intraperitoneal doses of vancomycin in continuous ambulatory peritoneal dialy sis patients.Nephron.1987; 45: 283–285.
