Recently several workers have described a β2-microglobulin-containing amyloid in patients on chronic hemodialysis. We have demonstrated that, in terms of the degree of elevation and the absence of correlation with duration of dialysis, the β2-microglobulin serum levels of CAPD patients are comparable to those on hemodialysis. Thus all dialysis patients seem to bear an increasing risk of tissue deposition of β2-microglobulin in the form of the newly-described amyloid, and this risk appears to be independent of the mode and duration of dialysis.
GejyoF., YamadaT., OdaniS.A new form of amyloid protein associated with chronic hemodialysis was identified as β2-microglobulin.Biochem Biophys Res Commun1985; 129: 701–6.
2.
ShirahamaT., SkinnerM., CohenA.S.Histochemical and immunohistochemical characterization of amyloid associated with chronic hemodialysis as β2-microglobulin.Lab Invest1985; 53: 705–9.
3.
SchwarzA., KellerF., SeyfertS.Carpal tunnel syndrome: A major complication in long-term hemodialysis patients.Clin Nephrol1984; 22: 133–7.
4.
SpertiniF., WautersJ.P., PoulenasI.Carpal tunnel syndrome; a frequent invalidating long-term complication of chronic hemodialysis.Clin Nephrol1984; 21: 98–101.
5.
ConnorsL.H., ShirahamaT., SkinnerM.In vitro formation of amyloid fibrils from intact β2-microglobulin.Biochem Biophys Res Commun1985; 131: 1063–8.
6.
GagnonR.F., LoughJ.O., BourgouinP.Carpal tunnel syndrome with β2 microglobulin containing amyloid during continuous ambulatory peritoneal dialysis. Submitted for publication.
BallardieF.W., KerrD.N.S., TennentG.Hemodialysis versus CAPD: Equal predisposition to amyloidosis?Lancet1986; 1: 795–6 (Letter).
9.
GejyoF., HommaN., SuzukiYSerum levels of β2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis.N Engl J Med1986; 314: 585–6 (Letter).
10.
KachelH.G., AltmeyerP., BaldamusC.A.Deposition of an amyloid-like substance as a possible complication of regular dialysis treatment.Contr Nephrol1983; 36: 127–131.
11.
KachelH.G., AltmeyerP., KuhnK.W.Deposition of nonamyloid material in connective tissue in uraemia.Blood Purification1984; 2: 142–8.
