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Abstract

We studied the percent delivery of insulin from CAPD dialysis solution bags used with and without the Peridex bacteriological filter. The studies were done in vitro using 125I trace. labelled insulin. The data demonstrate that most of the insulin added to bags of dialysis solution during CAPD is delivered into the peritoneal cavity. The mean (± S.D.) amount of insulin delivered for the trials without filters was 99 (± 5) %. For the group with filters, the mean was 75 (± 8)%. The difference was statistically significant (P < 0.001). Also, a statistically significant (P < 0.03) difference was observed between the data from the first three uses of new tubing sets versus subsequent uses.

We conclude that the insulin prescriptions of most diabetics will not require alteration when they change from CAPD without a Peridex filter to CAPD with the filter.

Keywords

insulin delivery in CAPD CAPD bacteriological filters

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References

Nolph

K.D.

Continuous ambulatory peritoneal dialysis (Editorial Review).

Am I Nephrol 1981; 1: 1–10.

Amair

, Khanna

, Leibel

Continuous ambulatory peritoneal dialysis in diabetics with end-stage renal disease.

N Engl I Med 1982; 306: 625–630.

Slingeneyer

, Mion

Peritonitis prevention in CAPD: Long term efficacy of a bacteriological filter (Abstract).

Proc Eur Dial Transplant Assoc 1982; 134.

Winchester

IF.

, Ash

S.R.

, Bousquet

Successful peritonitis reduction with a unidirectional bacteriologic CAPD filter (Abstract).

American Society for Artificial Internal Organs 1983; 12: 71.

Slingeneyer

, Mion

, Despaux

Use of bacteriologic filter in the prevention of peritonitis associated with peritoneal dialysis: Long term clinical results in intermittent and continuous ambulatory peritoneal dialysis. In: Atkins

R.C.

eds. Peritoneal dialysis. New York: Churchill Livingstone, 1981; 301–12.

Webel

S.S.

, Wood

W.A.

, Jackson

E.A.

Availability of insulin from parenteral nutrient solutions.

Am I Hosp Pharm 1977; 34: 353–357.

Butler

L.D.

, Munson

I.M.

, DeLuca

P.P.

Effect of inline filtration on the potency of low- dose drugs.

Am I Hosp Pharm 1980; 37: 935–941.

Wingert

T.D.

, Levin

S.R.

Insulin adsorption to an air-eliminating inline filter.

Am I Hosp Pharm 1981; 38: 382–383.

Weisenfeld

, Podolsky

, Goldsmith

, Ziff

Adsorption of insulin to infusion bottles and tubing.

Diabetes 1968; 17: 766–771.

10.

Schildt

, Ahlgren

, Berghern

, Wendt

Adsorption of insulin by infusion materials.

Acta Anaesthesiol Scand 1978; 22: 556–562.

11.

Hirsch

I.I.

, Fratkin

M.I.

, Wood

I.H.

, Thomas

R.B.

Clinical significance of insulin adsorption by polyvinyl chloride infusion systems.

Am J Hosp Pharm 1977; 34: 583–588.

12.

Kerchner

, Colaluca

D.M.

, Iuhl

R.P.

Effect of whole blood on insulin adsorption onto intravenous infusion systems.

Am J Hosp Pharm 1980; 37: 1323–1325.

13.

Siegel

Nonparametric Statistics For The Behavioral Sciences. New York: McGraw-Hill, 1956: 116–121.

14.

Amidon

, Reichert

I.E.

, Johnson

C.A.

Adsorption of insulin to the polyvinyl chloride surface of CAPD solution containers.

Proc Dial Transplant Forum 1980; 296–298.

15.

Wideroe

T-E

, Smeby

L.C.

, Berg

Intraperitoneal (1251) insulin absorption during intermittent and continuous peritoneal dialysis.

Kidney Int 1983; 23: 22–28.

16.

Shapiro

, Blumenkrantz

, Levin

S.R.

, Coburn

I.W.

Absorption and action of insulin added to peritoneal dialysate in dogs.

Nephron 1979; 23: 174–180.

17.

Crossley

, Kjellstrand

C.M.

Intraperitoneal insulin for control of blood sugar in diabetic patients during peritoneal dialysis.

Br Med J 1971; 1: 269–270.

18.

Roscoe

I.M.

Practices of insulin administration in CAPD.

Perit Dial Bull 1982; 2: S27–S31.

Insulin Delivery from Continuous Ambulatory Peritoneal Dialysis Bags Used with Peridex Filters

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