It seems that CAPD may improve some patients with osteomalacia but may be similar to hemodialysis in regard to osteitis fibrosa. However, long-term prospective evaluation of the incidence of bone disease in CAPD patients is necessary before we can determine how CAPD may alter the incidence and expression of renal osteodystrophy. We need more information before we can conclude that CAPD may improve pure osteomalacia. Finally, the data available are insufficient to clarify the role of vitamin D analogues in these patients.
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References
1.
FelsenfeldA., LlachF.Vitamin D and metabolic bone disease: A clinicopathologic overview.Pathol Ann1982; 17: 383–406.
2.
FelsenfeldA., HarrelsonJ.M., GutmanR.A.A quantitative histomorphometric comparison of 40 micron thick paragon sections with 5 micron thick goldner section in the study of undecalcified bone.Calcif Tissue Int1982; 34: 232–238.
3.
OttS.M., MaloneyN.A.Coburn JW. The prevention histomorphometric (BH) (abstract). Ann Meeting of bone aluminum deposition i renal Am Soc Nephrol 1981: 534. osteodystrophy and its relation to the response to calcitriol therapy.NEJM1982; 307: 709–713.
4.
ParkinsonI.S., FeestT.G., WardM.D.Fracturing dialysis osteodystrophy and encephalopathy. An epidemiological study.Lancet1979; 1: 406–409.
5.
FelsenfeldA.J., GutmanR.A., LlachF.Osteomalacia with low parathyroid hormone in chronic renal failure: A syndrome previously reported only with maintenance dialysis.Am J Nephrology1982; 2: 147–154.
6.
PlattsM.M., GoodeC.C., HislopJ.S.Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis.Br Med J1977; 2: 657–660.
7.
SlatopolskyE., CaglarS., Pennel1J.P.On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog.J Clin Invest1971; 50: 492–499.
8.
LlachF., MassryS.G., SingerF.R.Skeletal resistance to endogenous parathyroid hormone in patients with early renal failure: A possible cause for secondary hyperparathyroidism.J Clin Endocrinol Metab1975; 412: 339–345.
9.
MassryS.G., CobumJ.W., LeeD.B.N.Skeletal resistance to parathyroid hormone in renal failure. Studies in 105 human subjects.Ann Intern Med1973; 78: 357–364.
10.
SlatopolskyE., GrayR., AdamsN.D.Low serum levels of 1,25 dihydroxy vitamin D3 are not responsible for the development of secondary hyperparathyroidism in early renal failure.Proc Ann Meeting Am Soc Nephrol1978; 11: 99A.
11.
GokalR., EllisH.A., RamosJ.M.Improvement in secondary hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis. In: GahlG.M., KesselM., NolphK.D., eds. Advances in peritoneal dialysis.Amsterdam: Excerpta Medica, 1981: 461–466.
12.
KurtzS.B., McCarthyJ.T., KumarR.Hypercalcemia in continuous ambulatory peritoneal dialysis (CAPD) patients: Observations on parameters on calcium metabolism. In: GahlG.M., KesselM., NolphK.D., eds. Advances in peritoneal dialysis.Amsterdam: Excerpta Medica. 1981: 467–577.
13.
TielemansC., AubryC., DratwaM.The effect of continuous ambulatory peritoneal dialysis (CAPD) on renal osteodystrophy. In: GahlG.M., KesselM., NolphK.D., eds. Advances in peritoneal dialysis.Amsterdam: Excerpta Medica, 1981: 455–460.
14.
CalderaroV., OreopoulosDo, MeemaE.H.Renal osteodystrophy in patients on continuous ambulatory peritoneal dialysis (CAPD): A biochemical and radiological study. In: MoncriefJ.W., PopovichR.P., eds. CAPD update.New York: Masson Publishing. 1981: 243–247.
15.
TeitelbaumS.L., FallonM.D., GearingB.K.The effects of continuous
