The pharmacokinetics of netilmicin were studied during 16 episodes of peritonitis in CAPD patients. An initial intraperitoneal dose of 10 mg of netilmicin per litre of dialysate gives a concentration adequate for most cases. This dose may have to be increased according to the respective minimal inhibitory concentrations (MICs) of the infecting organisms.
OreopoulosD.G., WilliamsP., KhannaR., VasS.I.Treatment of peritonitis.Perit Dial Bull1981; I: S17–S19.
6.
DigranesA., DubbW.L., OstervoldB.The in vitro activity of netilmicin against 357 clinical isolates of Entero bacteriaceae, Pseudomonas aeruginosa, and Staphylococcus aureus. In: Nordic Netilmicin Symposium (Faber V, Nordbring F, and Solberg CO). Scand I Infect Dis1980: 23: S30–S33
7.
LeighD.A., MarrimerI., and OsboumeM.In-vitro comparison of netilmicin and other aminoglycosides against multiple resistant strains of Escherichia coli, Klebsiella aerogenes and Enterobacter cloacae and strains of Pseudomonas aerugino.l'a. In: Netilmicin a recent advance in aminoglycoside therapy. (RichardsonR.G., ed.) Roy Soc Med Int Cong Symp Ser No. 50. Royal Society of Medicine, London; Academic Press, London; and Stratton, New York. 1982: 15–19.
8.
DahlagerI.I.The effect of netilmicin and other aminoglycosides on renal function. A survey of the literature on the nephrotoxicity of netilmicin. In: Nordic netilmicin symposium, (FaberV., NordbringF., and SolbergC.O. eds.) Scand I Infect Dis1980; 23: S96–S102
9.
TjernstromO.Prospective evaluation of vestibular and auditory function in 76 patients treated with netilmicin. In: Nordic netilmicin symposium, (FaberV., NordbringF., SolbergC.O. eds.) Scand I Infect Dis1980; 23: S122–S125
10.
GokalR., RamosI.M., FrancisD.M.A.Peritonitis in continuous ambulatory peritoneal dialysis.Lancet1982; ii: 1388–1391.
ReynoldsA.V., Hamilton-MillerI.M.T., BrumfittW.Newer aminoglycosides -amikacin and tobramycinn: An in vitro comparison with kanamycin and gentamicin.B.M.I.1974; 3: 778–780.
13.
VasS.I., DuweA., WeatherheadI.Natural defence mechanisms of the peritoneum. The effect of peritoneal dialysis fluid on polymorphonuclear cells. In: Peritoneal dialysis (AtkinsR.C., eds. Churchill Livingstone.Edinburgh, 1981; 41–51.
