The disposition of intravenous (IV) tobramycin was studied in six patients on CAPD without peritonitis.
Tobramycin half-life was 34.6 h, the mean peritoneal clearance was 4.2 ml/min and the mean total body clearance was 8.0 ml/min. The amount of tobramycin removed during 24 hours on CAPD was approximately 20 mg, representing about 20.5% of the dose administered. Peak dialysate concentrations at the end of the first dwell varied from 1.8 to 3.1 ug/ml. Patients who r∼quire tobramycin for extraperitoneal infection should receive a loading dose of about 1.5 mg/kg, and a maintenance dose of 0.75 mg/kg every 36 hours.
OreopoulosD.G., RobsonM., IzattSA simple and safe technique for continuous ambulatory peritoneal dialysis (CAPD).Trans Am Soc Artif Intern Organs1978; 24: 484–489.
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RubinI., RogersW A., TaylorHMPeritonitis during continuous ambulatory peritoneal dialysis.Ann Intern Med1980; 92: 7–13.
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GreenblattDl, Koch-WeserI.Clinical phannacokinetics.N Engl I Med1975; 293: 702–705, 964-970.
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PatonT.W., ManuelM.A., WalkerS.E.Cimetidine disposition in patients on continuous ambulatory peritoneal dialysis.Perit Dial Bull1982; 2: 73–76.
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LockwoodW.R., BowerID.Tobramycin and gentamicin concentrations in serum of nonnal and anephric patients.Antirnicrob Agents Chemother1973; 3: 125129.
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IaffeG., MeyersB.R., HirchmanS.Z.Phannacokinetics of tobramycin in patients with stable renal impainnent: Patients undergoing peritoneal dialysis and patients on chronic hemodialysis.Antirnicrob Agents Chemother1972; 5: 611616.
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RamosE., AdairI.A., ShenYLPhannacokinetics of tobramycin in patients undergoing peritoneal dialysis (Abstract). Presented at the Am Soc of Nephrology 12th Annual Meeting. 1979: 126A.
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MawerG.E., AhmadR., DobbsSMPrescribing aids for gentaIIIicin.Br I Clin Phannac1974; 1: 45–50.
