To evaluate the influence of dialysis techniques on cellular immunity, we studied the immunological status of 52 ESRD patients treated by various dialytic methods: 22 by CAPD, eight byhemofiltration and 22 by hemodialysis. The patients were studied before treatment, and one, three, five and seven months after treatment. As markers of cellular and humoral immunity, we used DNCB and PPD skin tests, E-rosettes, active E-rosettes, the E-rosette inhibition test, surface-membrane immunoglobulins -C3 and C4, serum immunoglobulins (lgG, IgA, IgM) and Creactive protein. Before and at one month after treatment, cellular immunity was impaired in all groups, while humoral immunity parameters were normal. Three to five months after treatment, six of 16 CAPD patients showed a positive response to the DNCB test, and E-rosettes had increased significantly indicating an improvement in cellular immunity. At the seventh month the results were unchanged.
Patients on hemodialysis or hemofilitration showed no change in either cellular or humoral immunity. Our data indicates that, unlike hemofiltration and hemodialysis, CAPD can improve cell-mediated immunity.
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