Experimental evidence suggests that vitamin D deficiency impairs cardiac structure and function. Our objective was to observe relationships between circulating levels of the cardiac natriuretic peptides and vitamin D levels in patients on chronic peritoneal dialysis.
Method
Measurements were made of circulating levels of 25-hydroxyvitamin D [25(OH)D] and plasma B-type natriuretic peptide (BNP) levels in patients receiving chronic peritoneal dialysis.
Results
Both BNP and the 1–76 amino-terminal fragment of pro-BNP correlated inversely with 25(OH)D levels (rs = –0.60, p = 0.007, and rs = –0.64, p = 0.003, respectively) in patients on peritoneal dialysis.
Conclusions
Vitamin D deficiency in chronic renal failure may impair cardiac function, as manifested by elevated levels of B-type cardiac natriuretic peptides.
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