The development of an adequate animal model for peritoneal research remains an object of concern. In vivo peritoneal dialysis (PD) research is hampered by the large variety of available models that make interpretation of results and comparison of studies very difficult. Species and strain of experimental animals, method of peritoneal access, study duration, measures of solute transport and ultrafiltration, and sampling for histology differ substantially among the various research groups. A collective effort to discuss the shortcomings and merits of the different experimental models may lead to a consensus on a standardized animal model of PD.
MortierS., De VrieseA.S., Van de VoordeJ., SchaubT.P., Passlick-DeetjenJ., LameireN.H.Hemodynamic effects of peritoneal dialysis solutions on the rat peritoneal membrane: Role of acidity, buffer choice, glucose concentration, and glucose degradation products.J Am Soc Nephrol2002; 13: 480–9.
2.
MortierS., De VrieseA.S., McLoughlinR.M., TopleyN., SchaubT.P., Passlick-DeetjenJ.Effects of conventional and new peritoneal dialysis fluids on leukocyte recruitment in the rat peritoneal membrane.J Am Soc Nephrol2003; 14: 1296–306.
3.
ZareieM., van LambalgenA.A., De VrieseA.S., Van GelderopE., LameireN., ter WeeP.M.Increased leukocyte rolling in newly formed mesenteric vessels in the rat during peritoneal dialysis.Perit Dial Int2002; 22: 655–62.
4.
JonassonP., BraideM.A commercially available PD fluid with high pH and low GDP induces different morphological changes of rat peritoneum in intermittent PD.Adv Perit Dial1998; 14: 48–53.
5.
Zakaria elR., SpainD.A., HarrisP.D., GarrisonR.N.Generalized dilation of the visceral microvasculature by peritoneal dialysis solutions.Perit Dial Int2002; 22: 593–601.
6.
De VrieseA.S., TiltonR.G., StephanC.C., LameireN.H.Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane.J Am Soc Nephrol2001; 12: 1734–41.
De VrieseA.S., LameireN.H.Intravital microscopy: An integrated evaluation of peritoneal function and structure.Nephrol Dial Transplant2001; 16: 657–60.
9.
MengerM.D., RichterS., YamauchiJ.I., VollmarB.Intravital microscopy for the study of the microcirculation in various disease states.Ann Acad Med Singapore1999; 28: 542–56.
10.
WangT., QureshiA.R., HeimburgerO., WaniewskiJ., BergstromJ., LindholmB.Daily exposure to dialysis fluid results in changes in peritoneal transport.Perit Dial Int1997; 17: 379–86.
11.
WangT., HeimburgerO., QureshiA.R., WaniewskiJ., BergstromJ., LindholmB.Physiological saline is not a biocompatible peritoneal dialysis solution.Int J Artif Organs1999; 22: 88–93.
12.
PengW.X., GuoQ.Y., LiuS.M., LiuC.Z., LindholmB., WangT.Comparison of three chronic dialysis models.Adv Perit Dial2000; 16: 51–4.
13.
MusiB., BraideM., WieslanderA., RippeA., AlbrektssonA., HenleT.Very high daily intraperitoneal doses of carbonyl compounds affect the morphology, but not the exchange characteristics, of rat peritoneum.Blood Purif2001; 19: 286–92.
14.
SlaterN.D., CopeG.H., RafteryA.T.Peritoneal ultrafiltration after chronic exposure to dialysis fluid.Perit Dial Int1992; 12: 48–50.
15.
ZeltzerE., KleinO., RashidG., KatzD., KorzetsZ., BernheimJ.Intraperitoneal infusion of glucose-based dialysate in the rat – an animal model for the study of peritoneal advanced glycation end-products formation and effect on peritoneal transport.Perit Dial Int2000; 20: 656–61.
16.
ParkM.S., KimJ.K., HolmesC., WeissM.F.Effects of bicarbonate/lactate solution on peritoneal advanced glycosylation end-product accumulation.Perit Dial Int2000; 20(Suppl 5): S33–8.
17.
RoweL., MillerT.E.Effect of dialysis on the clearance of Staphylococcus epidermidis from the peritoneal cavity: An experimental evaluation.Clin Nephrol1993; 40: 106–13.
18.
FindonG., MillerT.Bacterial peritonitis in continuous ambulatory peritoneal dialysis: Effect on dialysis on host defense mechanisms.Am J Kidney Dis1995; 26: 765–73.
19.
MillerT.E., FindonG., RoweL.Characterization of an animal model of continuous peritoneal dialysis in chronic renal impairment.Clin Nephrol1992; 37: 42–7.
20.
LameireN., Van BiesenW., Van LandschootM., WangT., HeimburgerO., BergstromJ.Experimental models in peritoneal dialysis: A European experience.Kidney Int1998; 54: 2194–206.
21.
KoksalI.T., UstaM.F., AkkoyunluG., ToptasB., GulkesenK.H., ErdogruT.The potential role of advanced glycation end product and iNOS in chronic renal failure-related testicular dysfunction. An experimental study.Am J Nephrol2003; 23: 361–8.
22.
LankischP.G., KoopH., WincklerK., QuellhorstE., SchmidtH.Experimental model for peritoneal dialysis in small laboratory animals.Clin Nephrol1975; 4: 251–2.
23.
KimY.L., KimS.H., KimJ.H., KimS.J., KimC.D., ChoD.K.Effects of peritoneal rest on peritoneal transport and peritoneal membrane thickening in continuous ambulatory peritoneal dialysis rats.Perit Dial Int1999; 19(Suppl 2): S384–7.
24.
KimY.L., ChoS., KimJ.C., ChoD.K., KimY.J., LarmO.Effect in a rat model of heparinized peritoneal dialysis catheters on bacterial colonization and the healing of the exit site.Perit Dial Int2001; 21(Suppl 3): S357–8.
25.
PawlaczykK., Garcia-LopezE., Kuzlan-PawlaczykM., HeimburgerO., BergstromJ., BreborowiczA.The effect of icodextrin-based solutions on peritoneal transport in rats undergoing chronic peritoneal dialysis.Perit Dial Int2001; 21(Suppl 3): S359–61.
26.
SuzukiK., KhannaR., NolphK.D., MooreH.L., TwardowskiZ.J.Effects of bicarbonate dialysis solution on peritoneal transport in rats.Adv Perit Dial1996; 12: 24–6.
27.
WieczorowskaK., KhannaR., MooreH.L., NolphK.D., TwardowskiZ.J.Rat model of peritoneal fibrosis: Preliminary observations.Adv Perit Dial1995; 11: 48–51.
28.
Wieczorowska-TobisK., KorybalskaK., PolubinskaA., RadkowskiM., BreborowiczA., OreopoulosD.G.In vivo model to study the biocompatibility of peritoneal dialysis solutions.Int J Artif Organs1997; 20: 673–7.
29.
PawlaczykK., Kuzlan-PawlaczykM., Wieczorowska-TobisK., PolubinskaA., BreborowiczA., OreopoulosD.Evaluation of the effect of uremia on peritoneal permeability in an experimental model of continuous ambulatory peritoneal dialysis in anephric rats.Adv Perit Dial1999; 15: 32–5.
30.
PawlaczykK., Kuzlan-PawlaczykM., AnderstamB., HeimburgerO., BergstromJ., WaniewskiJ.Effects of intraperitoneal heparin on peritoneal transport in a chronic animal model of peritoneal dialysis.Nephrol Dial Transplant2001; 16: 669–71.
31.
Wieczorowska-TobisK., BrelinskaR., BreborowiczA., OreopoulosD.G.Morphologic aspects of chronic peritoneal dialysis in a rat model.Perit Dial Int2001; 21(Suppl 3): S342–4.
32.
Wieczorowska-TobisK., PolubinskaA., WisniewskaJ., PawlaczykK., Kuzlan-PawlaczykM., FilasV.Multidirectional approach to study peritoneal dialysis fluid biocompatibility in a chronic peritoneal dialysis model in the rat.Nephrol Dial Transplant2001; 16: 655–6.
33.
NakamotoH., ImaiH., IshidaY., YamanouchiY., InoueT., OkadaH.New animal models for encapsulating peritoneal sclerosis – role of acidic solution.Perit Dial Int2001; 21(Suppl 3): S349–53.
34.
ImaiH., NakamotoH., FucshimaR., YamanouchiY., IshidaY., SuzukiH.Glucocorticoid protects against the development of encapsulating peritoneal sclerosis on peritoneal dialysis.Adv Perit Dial2002; 18: 124–30.
35.
ImaiH., NakamotoH., FukushimaR., IshidaY., YamanouchiY., SuzukiH.Role of adhesion molecules in the progression of peritoneal sclerosis.Adv Perit Dial2003; 19: 180–5.
36.
ParkS.E., TwardowskiZ.J., MooreH.L., KhannaR., NolphK.D.Chronic administration of iron dextran into the peritoneal cavity of rats.Perit Dial Int1997; 17: 179–85.
37.
Pecoits-FilhoR.F., TwardowskiZ.J., KimY.L., KhannaR., MooreH., NolphK.D.The absence of toxicity in intraperitoneal iron dextran administration: A functional and histological analysis.Perit Dial Int1998; 18: 64–70.
38.
LeeJ.H., ReddyD.K., SaranR., MooreH.L., TwardowskiZ.J., NolphK.D.Peritoneal accumulation of advanced glycosylation end-products in diabetic rats on dialysis with icodextrin.Perit Dial Int2000; 20(Suppl 5): S39–47.
39.
HekkingL.H., HuijsmansA., Van GelderopE., WieslanderA.P., HavenithC.E., van den BornJ.Effect of PD fluid instillation on the peritonitis-induced influx and bacterial clearing capacity of peritoneal cells.Nephrol Dial Transplant2001; 16: 679–82.
40.
MargettsP.J., KolbM., YuL., HoffC.M., GauldieJ.A chronic inflammatory infusion model of peritoneal dialysis in rats.Perit Dial Int2001; 21(Suppl 3): S368–72.
41.
HekkingL.H., AaldersM.C., Van GelderopE., ZweersM.M., StruijkD.G., HavenithC.E.Effect of peritoneal dialysis fluid measured in vivo in a rat-model of continuous peritoneal dialysis.Adv Perit Dial1998; 14: 14–18.
42.
HekkingL.H., ZareieM., DriesprongB.A., FaictD., WeltenA.G., de GreeuwI.Better preservation of peritoneal morphologic features and defense in rats after long-term exposure to a bicarbonate/lactate-buffered solution.J Am Soc Nephrol2001; 12: 2775–86.
43.
ZareieM., HekkingL.H., WeltenA.G., DriesprongB.A., Schadee-EestermansI.L., FaictD.Contribution of lactate buffer, glucose and glucose degradation products to peritoneal injury in vivo.Nephrol Dial Transplant2003; 18: 2629–37.
44.
ZareieM., HekkingL.H.P., DriesprongB.A.J., ter WeeP.M., BeelenR.H.J., van den BornJ.Accumulation of omental mast cells during peritoneal dialysis.Perit Dial Int2001; 21(Suppl 3): S373–6.
45.
HekkingL.H., HarveyV.S., HavenithC.E., van den BornJ., BeelenR.H., JackmanR.W.Mesothelial cell transplantation in models of acute inflammation and chronic peritoneal dialysis.Perit Dial Int2003; 23: 323–30.
46.
ZweersM.M., SplintL.J., KredietR.T., StruijkD.G.Ultrastructure of basement membranes of peritoneal capillaries in a chronic peritoneal infusion model in the rat.Nephrol Dial Transplant2001; 16: 651–4.
47.
De VrieseA.S., MortierS., CornelissenM., PalmansE., VanackerN.J., LeyssensA.The effects of heparin administration in an animal model of chronic peritoneal dialysate exposure.Perit Dial Int2002; 22: 566–72.
48.
MortierS., De VrieseA.S., LeyssensA., VanackerN.J., FaictD., CornelissenM.Antibiotic administration in an animal model of chronic peritoneal dialysate exposure.Perit Dial Int2003; 23: 331–8.
49.
MortierS., FaictD., SchalkwijkC., LameireN., De VrieseA.Long-term exposure to new peritoneal dialysis solutions: Effects on the peritoneal membrane.Kidney Int2004; 66: 1257–65.
50.
MortierS., FaictD., LameireN.H., De VrieseA.S.Benefits of switching from a conventional to a low-GDP bicarbonate/lactate-buffered dialysis solution in a rat model.Kidney Int2004 [in press].
51.
de WaartD.R., ZweersM.M., StruijkD.G., KredietR.T.Icodextrin degradation products in spent dialysate of CAPD patients and the rat, and its relation with dialysate osmolality.Perit Dial Int2001; 21: 269–74.
52.
GotloibL., WaisbrutV., ShostakA., KushnierR.Acute and long-term changes observed in imprints of mouse mesothelium exposed to glucose-enriched, lactated, buffered dialysis solutions.Nephron1995; 70: 466–77.
53.
GotloibL., WajsbrotV., ShostakA., KushnierR.Effect of hyperosmolality upon the mesothelial monolayer exposed in vivo and in situ to a mannitol-enriched dialysis solution.Nephron1999; 81: 301–9.
54.
NiJ., MoulinP., GianelloP., FeronO., BalligandJ.L., DevuystO.Mice that lack endothelial nitric oxide synthase are protected against functional and structural modifications induced by acute peritonitis.J Am Soc Nephrol2003; 14: 3205–16.
55.
SchambyeH.T., FlesnerP., PedersenR.B., Hardt-MadsenM., ChemnitzJ., ChristensenH.K.Bicarbonate- versus lactate-based CAPD fluids: A biocompatibility study in rabbits.Perit Dial Int1992; 12: 281–6.
56.
Di PaoloN., GarosiG., PetriniG., TraversariL., RossiP.Peritoneal dialysis solution biocompatibility testing in animals.Perit Dial Int1995; 15(7 Suppl): S61–9.
57.
ZweersM.M., DoumaC.E., de WaartD.R., van der WardtA.B., Ho-dac-PannekeetM.M., KredietR.T.The standard peritoneal permeability analysis in the rabbit: A longitudinal model for peritoneal dialysis.Perit Dial Int1999; 19: 56–64.
58.
GarosiG., Di PaoloN.The rabbit model in evaluating the biocompatibility in peritoneal dialysis.Nephrol Dial Transplant2001; 16: 664–5.
59.
BreborowiczA., KnapowskiJ.Augmentation of peritoneal dialysis clearance with procaine.Kidney Int1984; 26: 392–6.
60.
TranL., RodelaH., HayJ.B., OreopoulosD., JohnstonM.G.Quantitation of lymphatic drainage of the peritoneal cavity in sheep: Comparison of direct cannulation techniques with indirect methods to estimate lymph flow.Perit Dial Int1993; 13: 270–9.
61.
MooreH.A chronic catheter model for PD exchanges in the ambulatory rat [Abstract].Perit Dial Int1992; 12(Suppl 2): S141.
62.
BeelenR.H.Role of omental milky spots in the local immune response.Lancet1992; 339: 689.
63.
Van VugtE., Van RijthovenE.A., KamperdijkE.W., BeelenR.H.Omental milky spots in the local immune response in the peritoneal cavity of rats.Anat Rec1996; 244: 235–45.
64.
De VrieseA.S., MortierS., LameireN.H.Non anticoagulant effects of heparin: Implications for animal models of peritoneal dialysis.Perit Dial Int2001; 21(Suppl 3): S354–6.
65.
KredietR.T., ZuyderhoudtF.M., BoeschotenE.W., AriszL.Alterations in the peritoneal transport of water and solutes during peritonitis in continuous ambulatory peritoneal dialysis patients.Eur J Clin Invest1987; 17: 43–52.
66.
DaviesS.J., BryanJ., PhillipsL., RussellG.I.Longitudinal changes in peritoneal kinetics: The effects of peritoneal dialysis and peritonitis.Nephrol Dial Transplant1996; 11: 498–506.
67.
DobbieJ.W.Pathogenesis of peritoneal fibrosing syndromes (sclerosing peritonitis) in peritoneal dialysis.Perit Dial Int1992; 12: 14–27.
68.
LinC.Y., ChenW.P., YangL.Y., ChenA., HuangT.P.Persistent transforming growth factor-beta 1 expression may predict peritoneal fibrosis in CAPD patients with frequent peritonitis occurrence.Am J Nephrol1998; 18: 513–19.
69.
MargettsP.J., GyorffyS., KolbM., YuL., HoffC.M., HolmesC.J.Antiangiogenic and antifibrotic gene therapy in a chronic infusion model of peritoneal dialysis in rats.J Am Soc Nephrol2002; 13: 721–8.
70.
CombetS., Van LandschootM., MoulinP., PiechA., VerbavatzJ.M., GoffinE.Regulation of aquaporin-1 and nitric oxide synthase isoforms in a rat model of acute peritonitis.J Am Soc Nephrol1999; 10: 2185–96.
71.
SuzukiK., KhannaR., NolphK.D., TwardowskiZ.J., MooreH.L.Expected white blood cell counts and differentials in a rat model of peritoneal dialysis.Perit Dial Int1995; 15: 142–6.
72.
PintoA.G., TwardowskiZ.J., NolphK.D., KhannaR., MooreH.L., ReddyD.K.Longitudinal changes in peritoneal membrane transport kinetics in normal rats.Perit Dial Int1999; 19: 72–4.
73.
FracassoA., BaggioB., OssiE., Del PreteD., BonfanteL., BazzatoG.Glycosaminoglycans prevent the functional and morphological peritoneal derangement in an experimental model of peritoneal fibrosis.Am J Kidney Dis1999; 33: 105–10.
74.
GuoW., WillenR., AnderssonR., ParssonH., LiuX., JohanssonK.Morphological response of the peritoneum and spleen to intraperitoneal biomaterials.Int J Artif Organs1993; 16: 276–84.
75.
Martin-MartinezM.D., StoenoiuM., VerkaerenC., DevuystO., DelporteC.Recombinant adenovirus administration in rat peritoneum: Endothelial expression and safety concerns.Nephrol Dial Transplant2004; 19: 1293–7.
76.
StoenoiuM.S., De VrieseA.S., BrouetA., MoulinP., FeronO., LameireN.Experimental diabetes induces functional and structural changes in the peritoneum.Kidney Int2002; 62: 668–78.
77.
CombetS., FerrierM.L., Van LandschootM., StoenoiuM., MoulinP., MiyataT.Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum.J Am Soc Nephrol2001; 12: 2146–57.
78.
WilliamsJ.D., CraigK.J., Von RuhlandC., TopleyN., WilliamsG.T.The natural course of peritoneal membrane biology during peritoneal dialysis.Kidney Int Suppl2003; 88: S43–9.
79.
WilliamsJ.D., CraigK.J., TopleyN., Von RuhlandC., FallonM., NewmanG.R.Morphologic changes in the peritoneal membrane of patients with renal disease.J Am Soc Nephrol2002; 13: 470–9.
80.
IshiiY., SawadaT., ShimizuA., TojimbaraT., NakajimaI., FuchinoueS.An experimental sclerosing encapsulating peritonitis model in mice.Nephrol Dial Transplant2001; 16: 1262–6.
81.
IoH., HamadaC., RoY., ItoY., HiraharaI., TominoY.Morphologic changes of peritoneum and expression of VEGF in encapsulated peritoneal sclerosis rat models.Kidney Int2004; 65: 1927–36.
82.
MargettsP.J., KolbM., GaltT., HoffC.M., ShockleyT.R., GauldieJ.Gene transfer of transforming growth factor-beta1 to the rat peritoneum: Effects on membrane function.J Am Soc Nephrol2001; 12: 2029–39.
83.
MotomuraY., KanbayashiH., KhanW.I., DengY., BlennerhassettP.A., MargettsP.J.The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-{beta} type II receptor gene transfer.Am J Physiol Gastrointest Liver Physiol2005; 288: G143–50.
