Glucose Degradation Products: Relationship with Cell Damage

Topley N. Membrane longevity in peritoneal dialysis: Impact of infection and bio-incompatible solutions. Adv Ren Replace Ther 1998; 5: 179–84.

Dobbie J.W. , Lloyd J.K. , Gall C.A. Categorization of ultra-structural changes in peritoneal mesothelium, stroma and blood vessels in uremia and CAPD patients. In: Khanna R. , Nolph K.D. , Prowant B.F. , Twardowski Z.J. , Oreopoulos D.G. , eds. Advances in peritoneal dialysis. Toronto: Peritoneal Dialysis Bulletin, 1990; 6: 3–12.

Coles G.A. Biocompatibility of various osmotic solutes. Perit Dial Int 1995; 15: S71–5.

Wieslander A.P. Cytotoxicity of peritoneal dialysis fluid. Nephrol Dial Transplant 1996; 11: 958–9.

Kjellstrand P. , Martinson E. , Wieslander A. , Holmquist B. Development of toxic degradation products during heat sterilization of glucose-containing fluids for peritoneal dialysis: Influence of time and temperature. Perit Dial Int 1995; 15: 26–32.

Martinson E. , Wieslander A.P. , Kjellstrand P.T. , Boberg U. Toxicity of heat sterilized peritoneal dialysis fluids is derived from degradation of glucose. ASAIO J 1992; 38: M370–2.

Martis L. , Henderson L.W. Impact of terminal heat sterilization on the quality of peritoneal dialysis solutions. Blood Purif 1997; 15: 54–60.

Wieslander A.P. , Kjellstrand P.T. , Rippe B. Heat sterilization of glucose-containing fluids for peritoneal dialysis: Biological consequences of chemical alterations. Perit Dial Int 1995; 15: S52–9.

Cooker L.A. , Luneburg P. , Faict D. , Choo C. , Holmes C.J. Reduced glucose degradation products in bicarbonate/lactate–buffered peritoneal dialysis solutions produced in two-chambered bags. Perit Dial Int 1997; 17: 373–8.

Sundaram S. , Cendoroglo M. , Cooker L.A. , Jaber B.L. , Faict D. , Holmes C.J. Effect of two-chambered bicarbonate/lactate–buffered peritoneal dialysis fluids on peripheral blood mononuclear cell and polymorphonuclear cell function in vitro. Am J Kidney Dis 1997; 30: 680–9.

Wieslander A. , Linden T. Glucose degradation and cytotoxicity in PD fluids. Perit Dial Int 1996; 16(Suppl 1): S114–18.

Henderson I.S. , Couper I.A. , Lumsden A. , Maher J.F. Potentially irritant glucose metabolites in unused CAPD fluid. In: Winchester J.F. , ed. Frontiers in peritoneal dialysis. New York: Field, Rich and Associates, Inc.; 1986: 261–4.

Henderson I.S. , Couper L.A. , Lumsden A. The effect of shelf-life of peritoneal dialysis fluid on ultrafiltration in CAPD. In: LaGreca G. , ed. Peritoneal dialysis. Proceedings of the 2nd International Course. Milan: Wichtig Editore; 1986: 85–6.

Wieslander A.P. , Nordin M.K. , Kjellstrand P.T. , Boberg U.C. Toxicity of peritoneal dialysis fluids on cultured fibro-blasts, L-929. Kidney Int 1991; 40: 77–9.

Wieslander A.P. , Andren A.H. , Nilsson–Thorell C. , Muscalu N. , Kjellstrand P.T. , Rippe B. Are aldehydes in heat-sterilized peritoneal dialysis fluids toxic in vitro? Perit Dial Int 1995; 15: 348–52.

Witowski J. , Korybalska K. , Wiesniewska J. , Breborowicz A. , Gahl G.M. , Frei U. Effect of glucose degradation products on human peritoneal mesothelial cell function. J Am Soc Nephrol 2000; 11: 729–39.

Topley N. The host's initial response to peritoneal infection: The pivotal role of the mesothelial cell. Perit Dial Int 1995; 15: 116–7.

Jörres A. , Witowski J. , Korybalska K. , Breborowicz A. , Gahl G.M. , Frei U. Effect of glucose degradation products on human peritoneal mesothelial cell proliferation and IL-6 production [Abstract]. Perit Dial Int 1998; 18: 113.

Jörres A. , Witowski J. , Korybalska K. , Breborowicz A. , Gahl G.M. , Frei U. Toxicity of glucose degradation products towards human peritoneal mesothelial cell and L929 fibroblasts [Abstract]. Kidney Blood Press Res 1998; 21: 200.

Witowski J. , Korybalska K. , Wisniewska J. , Breborowicz A. , Gahl G.M. , Frei U. Human peritoneal mesothelial cells exposed chronically to glucose degradation products display impaired viability and function [Abstract]. J Am Soc Nephrol 1999; 10: 325A.

Witowski J. , Korybalska K. , Wisniewska J. , Breborowicz A. , Gahl G.M. , Frei U. Prolonged exposure to glucose degradation products impairs the function of human peritoneal mesothelial cells in vitro [Abstract]. In: Proceedings of the XVth International Congress of Nephrology; 2–6 May 1999; Buenos Aires, Argentina. Buenos Aires; 1999: 1213.

Jonasson P. , Braide M. Acute in vivo toxicity of heat-sterilized glucose peritoneal dialysis fluids to rat peritoneal macrophages. Perit Dial Int 1998; 18: 376–81.

Jonasson P. , Bagge U. , Wieslander A. , Braide M. Heat-sterilized PD fluid blocks leukocyte adhesion and increases flow velocity in rat peritoneal venules. Perit Dial Int 1996; 16(Suppl 1): S137–40.

Musi B. , Carlsson O. , Rippe A. , Wieslander A. , Rippe B. Effects of acidity, glucose degradation products, and dialysis fluid buffer choice on peritoneal solute and fluid transport in rats. Perit Dial Int 1998; 18: 303–10.

Nakayama M. , Kawaguchi Y. , Yamada K. , Hasegawa T. , Takazoe K. , Katoh N. Immunohistochemical detection of advanced glycosylation end-products in the peritoneum and its possible pathophysiological role in CAPD. Kidney Int 1997; 51: 182–6.

Millar D.J. , Thornalley P.J. , Dawnay A. In vitro AGE formation with methylglyoxal—A glucose breakdown product in diabetic sera and PD fluid [Abstract]. J Am Soc Nephrol 1998; 9: 288A.

Niwa H. , Takeda A. , Wakai M. , Miyata T. , Yasuda Y. , Mitsuma T. Accelerated formation of N epsilon-(carboxymethyl)lysine, an advanced glycation end product, by glyoxal and 3-deoxyglucosone in cultured rat sensory neurons. Biochem Biophys Res Commun 1998; 248: 93–7.

Wells–Knecht K.J. , Brinkmann E. , Wells–Knecht M.C. , Litchfield J.E. , Ahmed M.U. , Reddy S. New biomarkers of Maillard reaction damage to proteins. Nephrol Dial Transplant 1996; 11(Suppl 5): 41–7.

Lamb E.J. , Cattell W.R. , Dawnay A.B. In vitro formation of advanced glycation end products in peritoneal dialysis fluid. Kidney Int 1995; 47: 1768–74.

Millar D.J. , Dawnay A.B.S. Heat sterilization of PD fluid promotes advanced glycation end-product (AGE) formation [Abstract]. J Am Soc Nephrol 1995; 6: 551.

Schalkwijk C.G. , Posthuma N. , ten Brink H.J. , ter Wee P.M. , Teerlink T. Induction of 1,2-dicarbonyl compounds, intermediates in the formation of advanced glycation end-products, during heat-sterilization of glucose-based peritoneal dialysis fluids. Perit Dial Int 1999; 19: 325–33.

Niwa T. , Miyazaki T. , Katsuzaki T. , Tatemichi N. , Takei Y. Serum levels of 3-deoxyglucosone and tissue contents of advanced glycation end products are increased in streptozotocin-induced diabetic rats with nephropathy. Nephron 1996; 74: 580–5.

Niwa T. , Takeda N. , Miyazaki T. , Yoshizumi H. , Tatematsu A. , Maeda K. Elevated serum levels of 3-deoxyglucosone, a potent protein-cross-linking intermediate of the Maillard reaction, in uremic patients. Nephron 1995; 69: 438–43.

Odani H. , Shinzato T. , Usami J. , Matsumoto Y. , Brinkmann Frye E. , Baynes J.W. Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: Evidence for increased oxidative stress in uremia. FEBS Lett 1998; 427: 381–5.

Wieslander A.P. , Deppisch R. , Svensson E. , Forsback G. , Speidel R. , Rippe B. In vitro biocompatibility of a heat-sterilized, low-toxic, and less acidic fluid for peritoneal dialysis. Perit Dial Int 1995; 15: 158–64.

Simonsen O. , Wieslander A. , Landgren C. , Rippe B. Less infusion pain and elevated level of cancer antigen 125 by the use of a new and more biocompatible PD fluid. In: Khanna R. , ed. Advances in peritoneal dialysis. Toronto: Peritoneal Dialysis Publications, 1996; 12: 156–60.

Cappelli G. , Bandiani G. , Cancarini G.C. , Feriani M. , Dell'Aquila R. , Saffioti S. Low concentrations of glucose degradation products in peritoneal dialysis fluids and their impact on biocompatibility parameters: Prospective cross-over study with a three-compartment bag. In: Khanna R. , ed. Advances in peritoneal dialysis. Toronto: Peritoneal Dialysis Publications, 1999; 15: 238–42.

Jörres A. , Bender T.O. , Finn A. , Witowski J. , Fröhlich S. , Gahl G.M. Biocompatibility and buffers: Effect of bicarbonate-buffered peritoneal dialysis fluids on peritoneal cell function. Kidney Int 1998; 54: 2184–93.

Topley N. In vitro biocompatibility of bicarbonate-based peritoneal dialysis solutions. Perit Dial Int 1997; 17: 42–7.

Nilsson–Thorell C.B. , Muscalu N. , Andren A.H. , Kjellstrand P.T. , Wieslander A.P. Heat sterilization of fluids for peritoneal dialysis gives rise to aldehydes. Perit Dial Int 1993; 13: 208–13.

Jellum E. , Borresen H.C. , Eldjarn L. The presence of furan derivatives in patients receiving fructose-containing solutions intravenously. Clin Chim Acta 1973; 47: 191–201.

Linden T. , Forsback G. , Deppisch R. , Henle T. , Wieslander A. 3-deoxyglucosone, a promoter of advanced glycation end products in fluids for peritoneal dialysis. Perit Dial Int 1998; 18: 290–3.

Cendoroglo M. , Sundaram S. , Groves C. , Ucci A.A. , Jaber B.L. , Pereira B.J. Necrosis and apoptosis of polymorpho-nuclear cells exposed to peritoneal dialysis fluids in vitro. Kidney Int 1997; 52: 1626–34.

Cendoroglo M. , Sundaram S. , Jaber B.L. , Pereira B.J. Effect of glucose concentration, osmolality, and sterilization process of peritoneal dialysis fluids on cytokine production by peripheral blood mononuclear cells and polymorphonuclear cell functions in vitro. Am J Kidney Dis 1998; 31: 273–82.

Cooker L.A. , Choo C.G. , Luneburg P. , Lamela J. , Holmes C.J. Effect of icodextrin peritoneal dialysis solution on cell proliferation in vitro. In: Khanna R. , ed. Advances in peritoneal dialysis. Toronto: Peritoneal Dialysis Publications, 1999; 15: 17–20.

Ing T.S. , Patel B.P. , Patel J.A. , Patel N.K. , Yu A.W. , Osman A. Effects of a pH 7.4, lactate-based and a pH 7.4, bicarbonate-based peritoneal dialysis solutions on neutrophil superoxide generation. Int J Artif Organs 1996; 19: 700–3.

Wieslander A.P. , Nordin M.K. , Martinson E. , Kjellstrand P.T. , Boberg U.C. Heat sterilized PD-fluids impair growth and inflammatory responses of cultured cell lines and human leukocytes. Clin Nephrol 1993; 39: 343–8.