Pathophysiology of Antinuclear Antibodies in Systemic Lupus Erythematosus and Related Diseases

Abstract

Antinuclear antibodies in systemic lupus erythematosus (SLE) and related diseases have been used for characterizing nuclear antigens and for elucidating immune mechanisms that drive the autoimmune response. Each disease has its own characteristic profile of antinuclear antibodies, which has been useful for diagnostic purposes. In the biological context, concepts emerging from studies on nuclear antigens and antibodies show that the autoimmune response is antigen-driven, that autoantigens are components of subcellular particles involved in important biosynthetic functions, and that the epitopes recognized by autoantibodies are active sites or functional domain regions of these antigens. An intriguing hypothesis is that activated intracellular particles are the immunogens that drive the autoimmune response.

Keywords

autoantibodies Sjogren's syndrome SS-A/RoSS-B/La

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References

Anderson NE , Rosenblum MK , Graves F. , Wiley RG , Posner JB (1988). Autoantibodies in paraneoplastic syndromes associated with small cell lung cancer. Neurology 38:1391-1398.

Imai H. , Nakano Y. , Kiyosawa K. , Tan EM (1993). Increasing titers and changing specificities of antinuclear antibodies in patients with chronic liver disease who develop hepatocellular carcinoma. Cancer 71:26-35.

Kiers L. , Altermatt HJ , Lennon VA (1991). Paraneoplastic anti-neuronal nuclear IgG autoantibodies (Type I) localize antigen in small cell lung carcinoma. Mayo Clinic Proc 66:1209-1216.

Kofler D. , Schur PH , Kunkel H. (1967). Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126:607-624.

Lerner MR , Steitz JA (1979). Autoantibodies to small nuclear RNAs complex with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci USA 76:5495-5499.

Pollard KM , Reimer G. , Tan EM (1987). Autoantibodies in scleroderma. Clin Exp Rheumatol 7(Suppl 3):57-62.

Rose NR , Mackay IR (1992). The autoimmune diseases. II. New York: Academic Press, Inc.

Tan EM (1989). Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 44:93-151.

Totoritis MC , Tan EM , McNally EM , Rubin RL (1988). Association of antibody to histone complex H2A-H2B with symptomatic procainamide-induced lupus. New Engl J Med 31:1431-1436.