Despite the advantages of in situ model studies, in vitro models are most important to provide insight into the mechanism of dental caries, the mechanisms of fluoride action, and profile screening.
In this reaction paper following Dr. White's review, the emphasis is, first, on the role of mobile fluoride (FL) in fluoride efficacy, the formation of "CaF2-like" material as fluoride reaction product, and on fluoride reaction product localization. Second, mineral assessment techniques are discussed. Finally, the main differences between caries lesion formation in vitro and in situ are considered.
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